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Description: Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein
Chemical Name: Ethyl 4-(4-(diethylamino)phenyl)-2-((2,4-difluorophenyl)amino)thiazole-5-carboxylate
Purity: ≥98% (HPLC)
Citations (3)
Literature (4)

Biological Activity for Dynarrestin

Dynarrestin is a dynein inhibitor. Inhibits hedgehog signaling in vitro (IC50 = 0.22 μM). Exhibits reversible inhibition of cytoplasmic dynein 1-dependent microtubule binding and cytoplasmic dynein 2-dependent intraflagellar transport. Inhibits tumor cell proliferation in a mouse medulloblastoma model.

Technical Data for Dynarrestin

M. Wt 431.5
Formula C22H23F2N3O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2222768-84-3
PubChem ID 137919864
Smiles CCOC(C1=C(C2=CC=C(N(CC)CC)C=C2)N=C(S1)NC3=C(C=C(C=C3)F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Dynarrestin

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 43.15 100

Preparing Stock Solutions for Dynarrestin

The following data is based on the product molecular weight 431.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.59 mL 23.17 mL
5 mM 0.46 mL 2.32 mL 4.63 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References for Dynarrestin

References are publications that support the biological activity of the product.

Höing et al (2018) Dynarrestin, a novel inhibitor or cytoplasmic dynein. Cell Chem.Biol. 25 357 PMID: 29396292

If you know of a relevant reference for Dynarrestin, please let us know.

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Keywords: Dynarrestin, Dynarrestin supplier, Dynarrestin, hedgehog, Hh, signaling, inhibitors, inhibits, dynein, cytoplasmic, Hedgehog, Signaling, 6526, Tocris Bioscience

3 Citations for Dynarrestin

Citations are publications that use Tocris products. Selected citations for Dynarrestin include:

Charles E et al (2019) Measles Virus Forms Inclusion Bodies with Properties of Liquid Organelles. J Virol 93 PMID: 31375591

Sandra L et al (2023) Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix. iScience 26 105965 PMID: 36824274

Jian et al (2021) Mechanical Counterbalance of Kinesin and Dynein Motors in a Microtubular Network Regulates Cell Mechanics, 3D Architecture, and Mechanosensing. ACS Nano 15 17528-17548 PMID: 34677937

Do you know of a great paper that uses Dynarrestin from Tocris? Please let us know.

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Literature in this Area

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