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Submit ReviewDynarrestin
Description: Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein
Chemical Name: Ethyl 4-(4-(diethylamino)phenyl)-2-((2,4-difluorophenyl)amino)thiazole-5-carboxylate
Purity: ≥98% (HPLC)
Biological Activity for Dynarrestin
Dynarrestin is a dynein inhibitor. Inhibits hedgehog signaling in vitro (IC50 = 0.22 μM). Exhibits reversible inhibition of cytoplasmic dynein 1-dependent microtubule binding and cytoplasmic dynein 2-dependent intraflagellar transport. Inhibits tumor cell proliferation in a mouse medulloblastoma model.
Technical Data for Dynarrestin
| M. Wt | 431.5 |
| Formula | C22H23F2N3O2S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2222768-84-3 |
| PubChem ID | 137919864 |
| InChI Key | UZNNDDDSGCMQOQ-UHFFFAOYSA-N |
| Smiles | CCOC(C1=C(C2=CC=C(N(CC)CC)C=C2)N=C(S1)NC3=C(C=C(C=C3)F)F)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Dynarrestin
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.15 | 100 |
Preparing Stock Solutions for Dynarrestin
The following data is based on the product molecular weight 431.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.32 mL | 11.59 mL | 23.17 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.63 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.32 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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Product Datasheets for Dynarrestin
References for Dynarrestin
References are publications that support the biological activity of the product.
Höing et al (2018) Dynarrestin, a novel inhibitor or cytoplasmic dynein. Cell Chem.Biol. 25 357 PMID: 29396292
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Keywords: Dynarrestin, Dynarrestin supplier, Dynarrestin, hedgehog, Hh, signaling, inhibitors, inhibits, dynein, cytoplasmic, Hedgehog, Signaling, 6526, Tocris Bioscience
3 Citations for Dynarrestin
Citations are publications that use Tocris products. Selected citations for Dynarrestin include:
Sandra L et al (2023) Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix. iScience 26 105965 PMID: 36824274
Jian et al (2021) Mechanical Counterbalance of Kinesin and Dynein Motors in a Microtubular Network Regulates Cell Mechanics, 3D Architecture, and Mechanosensing. ACS Nano 15 17528-17548 PMID: 34677937
Charles E et al (2019) Measles Virus Forms Inclusion Bodies with Properties of Liquid Organelles. J Virol 93 PMID: 31375591
Do you know of a great paper that uses Dynarrestin from Tocris? Please let us know.
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