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Submit ReviewDynarrestin
Description: Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein
Chemical Name: Ethyl 4-(4-(diethylamino)phenyl)-2-((2,4-difluorophenyl)amino)thiazole-5-carboxylate
Purity: ≥98% (HPLC)
Biological Activity
Dynein inhibitor. Inhibits hedgehog signaling in vitro (IC50 = 0.22 μM). Exhibits reversible inhibition of cytoplasmic dynein 1-dependent microtubule binding and cytoplasmic dynein 2-dependent intraflagellar transport. Inhibits tumor cell proliferation in a mouse medulloblastoma model.
Technical Data
| M. Wt | 431.5 |
| Formula | C22H23F2N3O2S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2222768-84-3 |
| PubChem ID | 137919864 |
| InChI Key | UZNNDDDSGCMQOQ-UHFFFAOYSA-N |
| Smiles | CCOC(C1=C(C2=CC=C(N(CC)CC)C=C2)N=C(S1)NC3=C(C=C(C=C3)F)F)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.15 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 431.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.32 mL | 11.59 mL | 23.17 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.63 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.32 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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References
References are publications that support the biological activity of the product.
Höing et al (2018) Dynarrestin, a novel inhibitor or cytoplasmic dynein. Cell Chem.Biol. 25 357 PMID: 29396292
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Keywords: Dynarrestin, Dynarrestin supplier, Dynarrestin, hedgehog, Hh, signaling, inhibitors, inhibits, dynein, cytoplasmic, Hedgehog, Signaling, 6526, Tocris Bioscience
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