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Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.
Fluorescent Analog also available.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||9.08||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 454.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||11.01 mL||55.05 mL||110.1 mL|
|1 mM||2.2 mL||11.01 mL||22.02 mL|
|2 mM||1.1 mL||5.51 mL||11.01 mL|
|10 mM||0.22 mL||1.1 mL||2.2 mL|
References are publications that support the biological activity of the product.
Fan et al (2014) The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem.Biol. 21 1680 PMID: 25484239
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