IHR 1

Pricing Availability Delivery Time Qty
Cat.No. 5554 - IHR 1 | C20H12Cl4N2O2 | CAS No. 548779-60-8
Description: Potent Smo antagonist
Chemical Name: N,N'-1,4-Phenylenebis[2,5-dichlorobenzamide]
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.

Fluorescent Analog also available.

Technical Data

M. Wt 454.13
Formula C20H12Cl4N2O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 548779-60-8
PubChem ID 2167042
InChI Key VCLHHRGZKNUOAQ-UHFFFAOYSA-N
Smiles ClC1=CC(C(NC2=CC=C(NC(C3=C(Cl)C=CC(Cl)=C3)=O)C=C2)=O)=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.08 20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 454.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 11.01 mL 22.02 mL
5 mM 0.44 mL 2.2 mL 4.4 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Fan et al (2014) The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem.Biol. 21 1680 PMID: 25484239


If you know of a relevant reference for IHR 1, please let us know.

View Related Products by Product Action

View all Smoothened Receptor Antagonists

Keywords: IHR 1, supplier, IHR1, potent, smoothened, smo, antagonists, hedgehog, signaling, inhibitors, inhibits, response, smoothened, receptors, Smoothened, Receptors, Hedgehog, Signaling, Smoothened, Receptors, Tocris Bioscience

Citations for IHR 1

Citations are publications that use Tocris products.

Currently there are no citations for IHR 1. Do you know of a great paper that uses IHR 1 from Tocris? If so please let us know.

Reviews for IHR 1

There are currently no reviews for this product. Be the first to review IHR 1 and earn rewards!

Have you used IHR 1?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling