IHR 1

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Cat.No. 5554 - IHR 1 | C20H12Cl4N2O2 | CAS No. 548779-60-8
Description: Potent Smo antagonist
Chemical Name: N,N'-1,4-Phenylenebis[2,5-dichlorobenzamide]
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro. Fluorescent analog IHR-Cy3 also available.

Technical Data

M. Wt 454.13
Formula C20H12Cl4N2O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 548779-60-8
PubChem ID 2167042
InChI Key VCLHHRGZKNUOAQ-UHFFFAOYSA-N
Smiles ClC1=CC(C(NC2=CC=C(NC(C3=C(Cl)C=CC(Cl)=C3)=O)C=C2)=O)=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.08 20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 454.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 11.01 mL 22.02 mL
5 mM 0.44 mL 2.2 mL 4.4 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Fan et al (2014) The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem.Biol. 21 1680 PMID: 25484239


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