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Biological Activity for Ciliobrevin A
Ciliobrevin A is a Hedgehog (Hh) pathway antagonist; blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo. Perturbs primary cilia formation; inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity.
Technical Data for Ciliobrevin A
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ciliobrevin A
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Ciliobrevin A
The following data is based on the product molecular weight 358.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.79 mL||13.96 mL||27.92 mL|
|5 mM||0.56 mL||2.79 mL||5.58 mL|
|10 mM||0.28 mL||1.4 mL||2.79 mL|
|50 mM||0.06 mL||0.28 mL||0.56 mL|
References for Ciliobrevin A
References are publications that support the biological activity of the product.
Hyman et al (2009) Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc.Natl.Acad.Sci.U.S.A. 106 14132 PMID: 19666565
Firestone et al (2012) Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature 484 7392 PMID: 22425997
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3 Citations for Ciliobrevin A
Citations are publications that use Tocris products. Selected citations for Ciliobrevin A include:
Shin et al (2015) Autophagy Regulates Formation of Primary Cilia in Mefloquine-Treated Cells. Biomol Ther (Seoul) 23 327 PMID: 26157548
Conzemius et al (2016) ICAM-1 Binding Rhinoviruses A89 and B14 Uncoat in Different Endosomal Compartments. J Virol 90 7934 PMID: 27334586
Poon et al (2019) Evolutionary modification of AGS protein contributes to formation of micromeres in sea urchins. Nat Commun 10 3779 PMID: 31439829
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.