Hedgehog (Hh) pathway antagonist; blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo. Perturbs primary cilia formation; inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 358.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.79 mL||13.96 mL||27.92 mL|
|5 mM||0.56 mL||2.79 mL||5.58 mL|
|10 mM||0.28 mL||1.4 mL||2.79 mL|
|50 mM||0.06 mL||0.28 mL||0.56 mL|
References are publications that support the products' biological activity.
Hyman et al (2009) Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc.Natl.Acad.Sci.U.S.A. 106 14132 PMID: 19666565
Firestone et al (2012) Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature 484 7392 PMID: 22425997
If you know of a relevant reference for Ciliobrevin A, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Ciliobrevin A, supplier, CiliobrevinA, supplier, hedgehog, Hh, pathway, antagonists, blocks, inhibits, inhibitors, Smo, smoothened, patched, ciliogenesis, cilia, microtubules, dynein, cytoplasmic, AAA+, ATPase, HPI-4, HPI-4, Hedgehog, Signaling, Stem, Cell, Signaling, Other, ATPases, Hedgehog, Signaling, Tocris Bioscience
1 Citation for Ciliobrevin A
Citations are publications that use Tocris products. Selected citations for Ciliobrevin A include:
Shin et al (2015) Autophagy Regulates Formation of Primary Cilia in Mefloquine-Treated Cells. Biomol Ther (Seoul) 23 327 PMID: 26157548
Do you know of a great paper that uses Ciliobrevin A from Tocris? If so please let us know.
Reviews for Ciliobrevin A
There are currently no reviews for this product. Be the first to review Ciliobrevin A and earn rewards!
Have you used Ciliobrevin A?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.