Smoothened (Smo) receptors are non-classical G-protein-coupled receptors that belong to the Frizzled family. Smoothened receptors lack the ability to directly interact with their endogenous ligand, Hedgehog (Hh). In the resting state, Smo receptors are bound to patched (Ptc).
Agonists |
Cat. No. | Product Name / Activity |
---|---|
4918 | GSA 10 |
Smo receptor agonist | |
4551 | Purmorphamine |
Smo receptor agonist | |
4366 | SAG |
Potent Smoothened receptor agonist; activates the Hedgehog signaling pathway | |
6390 | SAG dihydrochloride |
Dihydrochloride salt of SAG; Smo receptor agonist | |
Antagonists |
Cat. No. | Product Name / Activity |
1623 | Cyclopamine |
Inhibitor of Hedgehog (Hh) signaling; Smo antagonist | |
5554 | IHR 1 |
Potent Smo antagonist | |
5561 | IHR-Cy3 |
Potent fluorescent Smo antagonist | |
5981 | Itraconazole |
SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623) | |
4717 | Jervine |
Inhibitor of Hedgehog (Hh) signaling; binds directly to Smo | |
4917 | M 25 |
Potent Smoothened (Smo) receptor antagonist | |
4585 | MRT 10 |
Smoothened (Smo) antagonist | |
6538 | PF 04449913 maleate |
Potent Smo antagonist | |
5262 | PF 5274857 hydrochloride |
High affinity and selective Smoothened (Smo) receptor antagonist | |
1974 | SANT-1 |
Inhibitor of Hedgehog (Hh) signaling; antagonizes smoothened activity | |
3617 | SANT-2 |
Inhibitor of Hedgehog (Hh) signaling; antagonizes smoothened activity | |
Other |
Cat. No. | Product Name / Activity |
4474 | 20(S)-Hydroxycholesterol |
Allosteric activator of Hedgehog signaling; induces Smo accumulation | |
4662 | SMANT hydrochloride |
Inhibits Smoothened (Smo) accumulation |
Smoothened (Smo) receptors are non-classical G-protein-coupled receptors that belong to the Frizzled family. Smoothened receptors lack the ability to directly interact with their endogenous ligand, Hedgehog (Hh). In the resting state, Smo receptors are bound to and repressed by patched (Ptc).
Upon Hh-Ptc interaction, Smo receptors are liberated and phosphorylated (activated). This initiates a signaling cascade that controls the activity of transcription factors belonging to the Gli family (particularly Cubitus interruptus (Ci)). Smo receptors are vital for embryogenesis (segmentation and appendage development) and are involved in maintenence of tissue homeostasis in adults. The human gene encoding the Smo receptor has been localized on chromosome 7q32.3.
Tocris offers the following scientific literature for Smoothened Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.