Smoothened Receptors
Smoothened (Smo) receptors are non-classical G-protein-coupled receptors that belong to the Frizzled family. Smoothened receptors lack the ability to directly interact with their endogenous ligand, Hedgehog (Hh). In the resting state, Smo receptors are bound to patched (Ptc).
Agonists |
|
|---|---|
| Cat No | Product Name / Activity |
| 4918 | GSA 10 |
| Smo receptor agonist | |
| 4551 | Purmorphamine |
| Smo receptor agonist | |
| 4366 | SAG |
| Potent Smoothened receptor agonist; activates the Hedgehog signaling pathway | |
Antagonists |
|
| Cat No | Product Name / Activity |
| 1623 | Cyclopamine |
| Inhibitor of Hedgehog (Hh) signaling; Smo antagonist | |
| 5554 | IHR 1 |
| Potent Smo antagonist | |
| 5561 | IHR-Cy3 |
| Potent fluorescent Smo antagonist | |
| 5981 | Itraconazole |
| SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623) | |
| 4717 | Jervine |
| Inhibitor of Hedgehog (Hh) signaling; binds directly to Smo | |
| 4917 | M 25 |
| Potent Smoothened (Smo) receptor antagonist | |
| 4585 | MRT 10 |
| Smoothened (Smo) antagonist | |
| 5262 | PF 5274857 hydrochloride |
| High affinity and selective Smoothened (Smo) receptor antagonist | |
| 1974 | SANT-1 |
| Inhibitor of Hedgehog (Hh) signaling; antagonizes smoothened activity | |
| 3617 | SANT-2 |
| Inhibitor of Hedgehog (Hh) signaling; antagonizes smoothened activity | |
Other |
|
| Cat No | Product Name / Activity |
| 4474 | 20(S)-Hydroxycholesterol |
| Allosteric activator of Hedgehog signaling; induces Smo accumulation | |
| 4662 | SMANT hydrochloride |
| Inhibits Smoothened (Smo) accumulation | |
Smoothened (Smo) receptors are non-classical G-protein-coupled receptors that belong to the Frizzled family. Smoothened receptors lack the ability to directly interact with their endogenous ligand, Hedgehog (Hh). In the resting state, Smo receptors are bound to and repressed by patched (Ptc).
Upon Hh-Ptc interaction, Smo receptors are liberated and phosphorylated (activated). This initiates a signaling cascade that controls the activity of transcription factors belonging to the Gli family (particularly Cubitus interruptus (Ci)). Smo receptors are vital for embryogenesis (segmentation and appendage development) and are involved in maintenence of tissue homeostasis in adults. The human gene encoding the Smo receptor has been localized on chromosome 7q32.3.
External sources of pharmacological information for Smoothened Receptors :
Literature for Smoothened Receptors
GPCR Product Listing
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
- Rhodopsin-like Receptors
- Secretin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
- GPCR Signaling
