AY 9944 dihydrochloride
Inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. Inhibits Δ7-dehydrocholesterol reductase (IC50 = 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. May also directly block the cellular response to Hh proteins. Teratogenic in vivo.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 464.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.15 mL||10.77 mL||21.54 mL|
|5 mM||0.43 mL||2.15 mL||4.31 mL|
|10 mM||0.22 mL||1.08 mL||2.15 mL|
|50 mM||0.04 mL||0.22 mL||0.43 mL|
References are publications that support the products' biological activity.
Cooper et al (1998) Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 280 1603 PMID: 9616123
Incardona and Eaton (2000) Cholesterol in signal transduction. Curr.Opin.Cell Biol. 12 193 PMID: 10712926
Kraml et al (1964) Inhibition of the conversion of 7-dehydrocholesterol to cholesterol by AY-9944. Biochem.Biophys.Res.Commun. 15 455 PMID: 4283982
Moebius et al (1998) Molecular cloning and expression of the human Δ7-sterol reductase. Proc.Natl.Acad.Sci.U.S.A. 95 1899 PMID: 9465114
If you know of a relevant reference for AY 9944 dihydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: AY 9944 dihydrochloride, supplier, inhibitors, inhibits, hedgehog, Hh, signaling, Δ7-dehydrocholesterol, Delta7-dehydrocholesterol, reductases, Signalling, DHCR, Reductase, Reductases, AY9944, dihydrochloride, Hedgehog, Signaling, Delta-Dehydrocholesterol, Reductase, Hedgehog, Signaling, Tocris Bioscience
Citations for AY 9944 dihydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for AY 9944 dihydrochloride. Do you know of a great paper that uses AY 9944 dihydrochloride from Tocris? If so please let us know.
Reviews for AY 9944 dihydrochloride
There are currently no reviews for this product. Be the first to review AY 9944 dihydrochloride and earn rewards!
Have you used AY 9944 dihydrochloride?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.