Vismodegib

Pricing Availability   Qty
Description: Potent hedgehog pathway inhibitor
Chemical Name: 2-Chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity for Vismodegib

Vismodegib is a potent hedgehog pathway inhibitor (IC50 = 3 nM). It causes tumor regressions in allograft medulloblastoma mice model and tumor growth inhibition in a xenograft mouse models of colorectal cancer. Vismodegib is orally bioavailable.

Technical Data for Vismodegib

M. Wt 421.3
Formula C19H14Cl2N2O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 879085-55-9
PubChem ID 24776445
InChI Key BPQMGSKTAYIVFO-UHFFFAOYSA-N
Smiles O=C(NC=1C=CC(Cl)=C(C1)C2=NC=CC=C2)C3=CC=C(C=C3Cl)S(=O)(=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Vismodegib

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.13 100

Preparing Stock Solutions for Vismodegib

The following data is based on the product molecular weight 421.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.87 mL 23.74 mL
5 mM 0.47 mL 2.37 mL 4.75 mL
10 mM 0.24 mL 1.19 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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References for Vismodegib

References are publications that support the biological activity of the product.

Robarge et al (2009) GDC-0449-a potent inhibitor of the hedgehog pathway. Bioorg.Med.Chem.Lett. 19 5576 PMID: 19716296

Wong et al (2009) Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor. Xenobiotica 39 850 PMID: 19845436

Wong et al (2011) Pharmacokinetic-pharmacodynamic analysis of vismodegib in preclinical models of mutational and ligand-dependent Hedgehog pathway activation. Clin.Cancer Res. 17 4682 PMID: 21610148


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Citations for Vismodegib

Citations are publications that use Tocris products.

Currently there are no citations for Vismodegib. Do you know of a great paper that uses Vismodegib from Tocris? Please let us know.

Reviews for Vismodegib

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Literature in this Area

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