Vasopressin Receptors

Vasopressin receptors are a group of G-protein-coupled receptors that mediate vasoconstriction, antidiuresis and ACTH release. They are currently divided into three subtypes, V1A, V1B and V2 and are closely related to oxytocin receptors (OT).

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
3126 d[Cha4]-AVP
Potent and selective human V1B agonist
3396 Desmopressin
Synthetic vasopressin analog; V1B and V2 agonist
2935 [Arg8]-Vasopressin
Antidiuretic hormone
2934 [Lys8]-Vasopressin
Antidiuretic hormone
3127 d[Leu4,Lys8]-VP
Selective V1B agonist

Antagonists

Cat No Product Name / Activity
3377 (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin
Selective vasopressin V1A antagonist
3924 OPC 21268
Orally active vasopressin V1 antagonist
2310 SR 49059
Selective, orally active vasopressin V1A receptor antagonist
5729 TASP 0390325
Potent and selective V1B receptor antagonist; orally bioavailable
5181 Tolvaptan
Potent and selective vasopressin V2 receptor antagonist; renoprotective and orally active

Other

Cat No Product Name / Activity
4625 TC OT 39
V1a vasopressin receptor antagonist; also oxytocin and V2 receptor partial agonist

Related Targets

    Vasopressin receptors are a group of G-protein-coupled receptors that mediate vasoconstriction, antidiuresis and ACTH release. They are currently divided into three subtypes, V1A, V1B and V2 and are closely related to oxytocin receptors (OT).

    V1A is coupled to Gq/11 proteins and is found at high density on smooth muscle cells. It is involved in regulation of blood pressure through arterial vasoconstriction and has been found to stimulate VEGF secretion. V1B is located in the hypothalamus, where it controls ACTH secretion, and in the pancreas, where it is involved in insulin release. V2 is coupled to Gs proteins and is found exclusively on the basolateral membrane of collecting duct cells in the kidney, where it regulates water excretion.

    External sources of pharmacological information for Vasopressin Receptors :

    Literature for Vasopressin Receptors

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    Vasopressin Receptor Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    V1A Human AVPR1A NM_000706 P37288
    Mouse Avpr1a NM_016847 Q62463
    Rat Avpr1a NM_053019 P30560
    V1B Human AVPR1B NM_000707 P47901
    Mouse Avpr1b NM_011924 Q9WU02
    Rat Avpr1b NM_017205 P48974
    V2 Human AVPR2 NM_000054 P30518
    Mouse Avpr2 NM_019404 O88721
    Rat Avpr2 NM_019136 Q00788