Pricing Availability   Qty
Description: Synthetic vasopressin analog; V1B and V2 agonist
Purity: ≥95% (HPLC)
Citations (1)
Literature (1)

Biological Activity for Desmopressin

Desmopressin is a synthetic vasopressin analog that acts as an agonist at V1B and V2 receptors (EC50 values are 11.4 and 23.9 nM and Ki values are 5.84 and 65.9 nM respectively). Prevents polycystic kidney disease formation and exhibits antidiuretic, antiproliferative, hemostatic and hypotensive activity in vivo.

Technical Data for Desmopressin

M. Wt 1069.22
Formula C46H64N14O12S2

(Modifications: X = Mpr, Arg-8 = D-Arg, Gly-9 = C-terminal amide, Cyclized = X-1 - Cys-6)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 16679-58-6
PubChem ID 5311065
Smiles NC(=O)CC[C@@H]1NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)CCSSC[C@H](NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](CCCNC(N)=N)C(=O)NCC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Desmopressin

Solubility Soluble to 4 mg/ml in water

Product Datasheets for Desmopressin

Certificate of Analysis / Product Datasheet
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References for Desmopressin

References are publications that support the biological activity of the product.

Saito et al (1997) 1-Desamino-8-D-arginine vasopressin (DDAVP) as an agonist on V1b vasopressin receptor. Biochem.Pharmacol. 53 1711 PMID: 9264324

Gomez et al (2006) Desmopressin and other synthetic vasopressin analogues in cancer treatment. Bull.Cancer 93 E7 PMID: 16517412

Torres (2008) Vasopressin antagonists in polycystic kidney disease. Semin.Nephrol. 28 306 PMID: 18519091

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Keywords: Desmopressin, Desmopressin supplier, Synthetic, vasopressin, analog, V1B, V2, agonists, Receptors, Vasopressin, 3396, Tocris Bioscience

1 Citation for Desmopressin

Citations are publications that use Tocris products. Selected citations for Desmopressin include:

Campos-Lira et al (2019) Dynamic Modulation of Mouse Locus Coeruleus Neurons by Vasopressin 1a and 1b Receptors. Front Neurosci 12 919 PMID: 30618551

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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