Oxytocin Receptors

Oxytocin receptors (OT) are G-protein-coupled receptors that mediate parturition and lactation. They are closely related to vasopressin receptors. Oxytocin receptors are coupled to Gq/11 proteins and are localized to the myoepithelial cells of the mammary gland.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
4852 Carbetocin
Oxytocin analog
1910 Oxytocin
Involved in uterine contraction and lactation
4625 TC OT 39
Potent non-peptide oxytocin receptor partial agonist; also V1a receptor antagonist
3933 WAY 267464 dihydrochloride
Potent non-peptide oxytocin receptor agonist

Antagonists

Cat No Product Name / Activity
6332 Atosiban
Potent oxytocin receptor antagonist
2641 L-368,899 hydrochloride
Potent, non-peptide oxytocin receptor antagonist
2410 L-371,257
Potent and selective oxytocin receptor antagonist

Related Targets

    Oxytocin receptors (OT) are G-protein-coupled receptors that mediate parturition and lactation. They are closely related to vasopressin receptors. Oxytocin receptors are coupled to Gq/11 proteins and are localized to the myoepithelial cells of the mammary gland, and are also expressed in the myometrium and endometrium of the uterus at the end of pregnancy.

    Oxytocin receptors are involved in smooth muscle contraction of the uterus during parturition and facilitate lactation. These receptors are widespread throughout the central nervous system and modulate a variety of behaviors. These include responses to stress and anxiety, social memory and recognition, bonding, and sexual and maternal behaviors. Antinociceptive effects of oxytocin have also been observed in experimental models. The human gene encoding the oxytocin receptor is localized to chromosome 3p25.

    External sources of pharmacological information for Oxytocin Receptors :

    Literature for Oxytocin Receptors

    GPCR

    GPCR Product Listing

    A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

    • Rhodopsin-like Receptors
    • Secretin-like Receptors
    • Glutamate Receptors
    • Frizzled Receptors
    • GPCR Signaling
    Peptide Hormone Receptors

    Peptide Hormone Receptors Product Listing

    A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

    • Anterior Pituitary Regulation
    • Blood Pressure Regulation
    • Feeding and Appetite Regulation
    • Glucose Regulation
    • Peptide Hormone Processing

    Oxytocin Receptor Gene Data

    Species Gene Symbol Gene Accession No. Protein Accession No.
    Human OXTR NM_000916 P30559
    Mouse Oxtr NM_001081147 P97926
    Rat Oxtr NM_012871 P70536