OPC 21268

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Cat.No. 3924 - OPC 21268 | C26H31N3O4 | CAS No. 131631-89-5
Description: Orally active vasopressin V1 antagonist
Chemical Name: N-[3-[4-[[4-(3,4-Dihydro-2-oxo-1(2H)quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]-acetamide
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for OPC 21268

OPC 21268 is a nonpeptide vasopressin V1 receptor antagonist. Displays greater affinity for rat V1 than human V1 (Ki values are 25 and 8800 nM respectively). Exhibits 1000-fold selectivity for V1 receptors over V2 receptors. Orally active.

Compound Libraries for OPC 21268

OPC 21268 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for OPC 21268

M. Wt 449.54
Formula C26H31N3O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 131631-89-5
PubChem ID 114904

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for OPC 21268

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 44.95 100
ethanol 11.24 25

Preparing Stock Solutions for OPC 21268

The following data is based on the product molecular weight 449.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.12 mL 22.24 mL
5 mM 0.44 mL 2.22 mL 4.45 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References for OPC 21268

References are publications that support the biological activity of the product.

Yamamura et al (1991) OPC-21268, an orally effective, nonpeptide vasopressin V1 receptor antagonist. Science 252 572 PMID: 1850553

Imaizumi et al (1992) Effects of OPC-21268, an orally effective vasopressin V1 receptor antagonist in humans. Hypertension 20 54 PMID: 1319959

Thibonnier et al (2000) A molecular model of agonist and nonpeptide antagonist binding to the human V1 vascular vasopressin receptor. J.Pharmacol.Exp.Ther. 294 195 PMID: 10871312

If you know of a relevant reference for OPC 21268, please let us know.

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Keywords: OPC 21268, OPC 21268 supplier, OPC21268, vasopressin, v1, v1r, avp, arginine, Vasopressin, Receptors, 3924, Tocris Bioscience

Citations for OPC 21268

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