SSR 149415

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Cat.No. 6195 - SSR 149415 | C30H32ClN3O8S | CAS No. 439687-69-1
Description: Potent and selective vasopressin V1B antagonist
Alternative Names: Nelivaptan
Chemical Name: (2S,4R)-1-[(3R)-5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-2,3-dihydro-3-(2-methoxyphenyl)-2-oxo-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for SSR 149415

SSR 149415 is a potent and selective vasopressin V1B antagonist (Ki values are 3.7 and 1.3 nM for native and recombinant rat V1b receptors, respectively). Displays >70-fold selectively for rat V1B over V1A, V2 oxytoxin and a range of other receptors and ion channels. Inhibits AVP-induced glucagon release in In-R1-G9 α-pancreatic cells in vitro. Inhibits stress-induced ACTH release and exhibits anxiolytic-like effects in anxiety models. Orally bioavailable.

Compound Libraries for SSR 149415

SSR 149415 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SSR 149415

M. Wt 630.11
Formula C30H32ClN3O8S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 439687-69-1
PubChem ID 9895468
Smiles COC1=CC(OC)=C(S(=O)(N2C([C@@](C3=CC(Cl)=CC=C23)(C4=C(C=CC=C4)OC)N5C[C@@H](C[C@H]5C(N(C)C)=O)O)=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SSR 149415

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 63.01 100
ethanol 63.01 100

Preparing Stock Solutions for SSR 149415

The following data is based on the product molecular weight 630.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.59 mL 7.94 mL 15.87 mL
5 mM 0.32 mL 1.59 mL 3.17 mL
10 mM 0.16 mL 0.79 mL 1.59 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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References for SSR 149415

References are publications that support the biological activity of the product.

Serradeil-Le Gal et al (2005) An overview of SSR149415, a selective nonpeptide vasopressin V1b receptor antagonist for the treatment of stress-related disorders. CNS Drug Rev. 11 53 PMID: 15867952

If you know of a relevant reference for SSR 149415, please let us know.

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Keywords: SSR 149415, SSR 149415 supplier, SSR149415, vasopressin, receptor, V1b, potent, selective, antagonists, antagonism, orally, bioavailable, Nelivaptan, Vasopressin, Receptors, 6195, Tocris Bioscience

Citations for SSR 149415

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