SSR 149415

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Description: Potent and selective vasopressin V1B antagonist
Alternative Names: Nelivaptan
Chemical Name: (2S,4R)-1-[(3R)-5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-2,3-dihydro-3-(2-methoxyphenyl)-2-oxo-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide
Purity: ≥98% (HPLC)
Citations (2)
Literature (1)

Biological Activity for SSR 149415

SSR 149415 is a potent and selective vasopressin V1B antagonist (Ki values are 3.7 and 1.3 nM for native and recombinant rat V1b receptors, respectively). Displays >70-fold selectively for rat V1B over V1A, V2 oxytoxin and a range of other receptors and ion channels. Inhibits AVP-induced glucagon release in In-R1-G9 α-pancreatic cells in vitro. Inhibits stress-induced ACTH release and exhibits anxiolytic-like effects in anxiety models. Orally bioavailable.

Compound Libraries for SSR 149415

SSR 149415 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SSR 149415

M. Wt 630.11
Formula C30H32ClN3O8S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 439687-69-1
PubChem ID 9895468
Smiles COC1=CC(OC)=C(S(=O)(N2C([C@@](C3=CC(Cl)=CC=C23)(C4=C(C=CC=C4)OC)N5C[C@@H](C[C@H]5C(N(C)C)=O)O)=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SSR 149415

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 63.01 100
ethanol 63.01 100

Preparing Stock Solutions for SSR 149415

The following data is based on the product molecular weight 630.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.59 mL 7.94 mL 15.87 mL
5 mM 0.32 mL 1.59 mL 3.17 mL
10 mM 0.16 mL 0.79 mL 1.59 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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Product Datasheets for SSR 149415

Certificate of Analysis / Product Datasheet
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References for SSR 149415

References are publications that support the biological activity of the product.

Serradeil-Le Gal et al (2005) An overview of SSR149415, a selective nonpeptide vasopressin V1b receptor antagonist for the treatment of stress-related disorders. CNS Drug Rev. 11 53 PMID: 15867952

If you know of a relevant reference for SSR 149415, please let us know.

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View all Vasopressin Receptor Antagonists

Keywords: SSR 149415, SSR 149415 supplier, SSR149415, vasopressin, receptor, V1b, potent, selective, antagonists, antagonism, orally, bioavailable, Nelivaptan, Vasopressin, Receptors, 6195, Tocris Bioscience

2 Citations for SSR 149415

Citations are publications that use Tocris products. Selected citations for SSR 149415 include:

Mengliang et al (2021) Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury. Elife 10 PMID: 34372969

Pung-Pung et al (2020) Arginine Vasopressin Modulates Ion and Acid/Base Balance by Regulating Cell Numbers of Sodium Chloride Cotransporter and H+-ATPase Rich Ionocytes. Int J Mol Sci 21 PMID: 32486459

Do you know of a great paper that uses SSR 149415 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.