(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin

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Cat.No. 3377 - (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin | Pmp-Tyr(Me)-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (Cyclic) | CAS No. 73168-24-8
Description: Selective vasopressin V1A antagonist
Datasheet
Citations
Literature

Biological Activity

Selective vasopressin V1A receptor antagonist. Inhibits vasopressin and oxytocin-induced increases in intracellular calcium concentrations in vitro (IC50 values are 5 and 30 nM respectively). Exhibits potent and prolonged antivasopressor activity and induces anxiolytic-like effects in the dorsal, but not ventral, hippocampus in vivo.

Technical Data

M. Wt 1151.38
Formula C52H74N14O12S2
Sequence YFQNCPRG

(Modifications: Tyr-1 = Pmp-Tyr(Me), Gly-8 = C-terminal amide)

Storage Store at -20°C
CAS Number 73168-24-8
PubChem ID 122173055
InChI Key QVQOGNOOAMQKCE-LOVRMFBOSA-N
Smiles COC1=CC=C(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC3=CC=CC=C3)NC2=O)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1151.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.87 mL 4.34 mL 8.69 mL
5 mM 0.17 mL 0.87 mL 1.74 mL
10 mM 0.09 mL 0.43 mL 0.87 mL
50 mM 0.02 mL 0.09 mL 0.17 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Kruszynski et al (1980) [1-(β-mercapto-β,β-cyclopentamethylenepropionic acid),2-(O-methyl)tyrosine]arginine-vasopressin and [1-(β-mercapto-β,β-cyclopentamethylenepropionic acid)]arginine-vasopressin, two highly potent antagonists of the vas J.Med.Chem. 23 364 PMID: 6892930

Spath et al (1996) Arginine vasopressin and oxytocin increase intracellular calcium and cAMP in human glomerular epithelial cells in culture. Kidney Blood Press.Res. 19 81 PMID: 8871886

Tsuchiya et al (2002) Vasopressin inhibits sarcolemmal ATP-sensitive K+ channels via V1 receptors activation in the guinea pig heart. Circ.J. 66 277 PMID: 11922278

Engin and Treit (2008) Dissociation of the anxiolytic-like effects of Avpr1a and Avpr1b receptor antagonists in the dorsal and ventral hippocampus. Neuropeptides 42 411 PMID: 18508119


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Keywords: (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin, supplier, Selective, vasopressin, V1A, antagonists, V2, Receptors, Vasopressin, Vasopressin, Receptors, Vasopressin, Receptors, Tocris Bioscience

Citations for (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin

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