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Antidiuretic hormone found in most mammalian species. Also acts as a neurotransmitter at synapses in the brain; increases [Ca2+]i in cultured rat hippocampal neurons.
(Modifications: Disulfide bridge between 1 - 6, Gly-9 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 0.50 mg/ml in water|
References are publications that support the biological activity of the product.
Migara et al (1999) [Arg8]-vasopressin-induced increase in intracellular Ca2+ concentration in cultutred rat hippocampal neurons. Brain Res.Bull. 49 343 PMID: 10452354
Chan et al (2000) Discovery and design of novel and selective vasopressin and oxyt. agonists and antagonists: the role of bioassays. Exp.Physiol. 85S 7S
Cowley et al (2000) Control of renal medulaary circulation by vasopressin V1 and V2 receptors in the rat. Exp.Physiol. 85S 223S
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Keywords: [Arg8]-Vasopressin, [Arg8]-Vasopressin supplier, Antidiuretic, hormone, V2, Receptors, V1, Vasopressin, AVP, 2935, Tocris Bioscience
2 Citations for [Arg8]-Vasopressin
Citations are publications that use Tocris products. Selected citations for [Arg8]-Vasopressin include:
Leroy et al (2018) A circuit from hippocampal CA2 to lateral septum disinhibits social aggression. Nature 564 213 PMID: 30518859
Nøhr et al (2017) The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. Neurochem Int 102 105 PMID: 27916541
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Reviews for [Arg8]-Vasopressin
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To determine the signaling pathways mediating the effect of V1 vasopressin VP, cells were incubated in the presence and absence of inhibitors.The role of protein kinases C (PKC) and B (PKB) mediating VP induced antiapoptosis in H32 cells was investigated.
Literature in this Area
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.