TC OT 39

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Cat.No. 4625 - TC OT 39 | CAS No. 479232-57-0
Description: Potent non-peptide oxytocin receptor partial agonist; also V1a receptor antagonist
Chemical Name: (2S)-N-[[4-[(4,10-Dihydro-1-methylpyrazolo[3,4-b][1,5]benzodiazepin-5(1H)-yl)carbonyl]-2-methylphenyl]methyl]-2-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)thioxomethyl]-1-pyrrolidinecarboxamide
Purity: ≥97% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent non-peptide oxytocin receptor partial agonist (EC50 values are 33 nM and 850 nM for the oxytocin receptor and V2 vasopressin receptor respectively). Also a V1a vasopressin receptor antagonist (Ki = 330 nM). Active in vivo in a rat model of uterine response.

Compound Libraries

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Technical Data

M. Wt 600.78
Formula C32H40N8O2S
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 479232-57-0
PubChem ID 24776341
InChI Key PAEBEUZTAPIOIO-UHFFFAOYSA-N
Smiles O=C(N5[C@H]([C@](N6CCN(C)CCC6)=S)CCC5)NCC(C(C)=C2)=CC=C2C(N1C(C=CC=C3)=C3NC(N(C)N=C4)=C4C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in 1eq. HCl and to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 600.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.66 mL 8.32 mL 16.65 mL
5 mM 0.33 mL 1.66 mL 3.33 mL
10 mM 0.17 mL 0.83 mL 1.66 mL
50 mM 0.03 mL 0.17 mL 0.33 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Frantz et al (2010) Subtlety of the structure-affinity and structure-efficacy relationships around a nonpeptide oxytocin receptor agonist. J.Med.Chem. 53 1546 PMID: 20104850

Pitt et al (2004) Non-peptide oxytocin agonists. Bioorg.Med.Chem.Lett. 14 4585 PMID: 15357997


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Keywords: TCOT39 nonpeptide oxytocin receptors partial agonists vasopressin potent V1A V2 Oxytocin Receptors

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GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

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Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

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