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TC OT 39
Potent non-peptide oxytocin receptor partial agonist (EC50 values are 33 nM and 850 nM for the oxytocin receptor and V2 vasopressin receptor respectively). Also a V1a vasopressin receptor antagonist (Ki = 330 nM). Active in vivo in a rat model of uterine response.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 600.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.66 mL||8.32 mL||16.65 mL|
|5 mM||0.33 mL||1.66 mL||3.33 mL|
|10 mM||0.17 mL||0.83 mL||1.66 mL|
|50 mM||0.03 mL||0.17 mL||0.33 mL|
References are publications that support the biological activity of the product.
Frantz et al (2010) Subtlety of the structure-affinity and structure-efficacy relationships around a nonpeptide oxyt. receptor agonist. J.Med.Chem. 53 1546 PMID: 20104850
Pitt et al (2004) Non-peptide oxyt. agonists. Bioorg.Med.Chem.Lett. 14 4585 PMID: 15357997
If you know of a relevant reference for TC OT 39, please let us know.
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Keywords: TC OT 39, TC OT 39 supplier, TCOT39, nonpeptide, oxytocin, receptors, partial, agonists, vasopressin, potent, V1A, V2, Oxytocin, Receptors, Vasopressin, 4625, Tocris Bioscience
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