You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Potent pan-ribosomal S6 protein kinase (RSK) inhibitor (IC50 values are 4 to 13 nM). Displays selectivity for RSK isoforms over other kinases. Inhibits RSK-dependent Y-box binding protein 1 (YB-1) phosphorylation in vitro. Suppresses growth of triple negative breast cancer cell lines.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 368.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.43 mL||27.15 mL||54.29 mL|
|2.5 mM||1.09 mL||5.43 mL||10.86 mL|
|5 mM||0.54 mL||2.71 mL||5.43 mL|
|25 mM||0.11 mL||0.54 mL||1.09 mL|
References are publications that support the biological activity of the product.
Jain et al (2015) Discovery of potent and selective RSK inhibitors as biological probes. J.Med.Chem. 58 6766 PMID: 26270416
Aronchik et al (2014) Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers. Mol.Cancer Res. 12 803 PMID: 24554780
Davies et al (2015) Inhibition of RSK with the novel small-molecule inhibitor LJI308 overcomes chemoresistance by eliminating cancer stem cells. Oncotarget. 6 20570 PMID: 26011941
If you know of a relevant reference for LJI308, please let us know.
View Related Products by Product Action
Keywords: LJI308, LJI308 supplier, LJI, 308, RSK1, RSK2, RSK3, RSK4, inhibitors, inhibits, ribosome, S6, protein, kinase, potent, RSK, 6754, Tocris Bioscience
Citations for LJI308
Citations are publications that use Tocris products.
Currently there are no citations for LJI308. Do you know of a great paper that uses LJI308 from Tocris? Please let us know.
Reviews for LJI308
There are currently no reviews for this product. Be the first to review LJI308 and earn rewards!
Have you used LJI308?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.