Pricing Availability   Qty
Description: Inhibits PKA/AKAP interactions; cell permeable
Purity: ≥95% (HPLC)
Citations (2)

Biological Activity for st-Ht31

st-Ht31 is a stearated form of the peptide Ht-31. Inhibits the interaction between the RII subunits of cAMP-dependent PKA and A-kinase anchoring protein (AKAP) in cell extracts. Cell permeable.

Technical Data for st-Ht31

M. Wt 2798.27
Formula C129H217N29O39

(Modifications: Asp-1 = N-terminal Ste)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 188425-80-1
PubChem ID 16143012
Smiles CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for st-Ht31

Solubility Soluble to 1 mg/ml in 0.01M PBS (pH 7.4)

Product Datasheets for st-Ht31

Certificate of Analysis / Product Datasheet
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References for st-Ht31

References are publications that support the biological activity of the product.

Gorshkov et al (2017) AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons. Nat.Chem.Biol. 13 425 PMID: 28192412

Vijayaraghavan et al (1997) Protein kinase A-anchoring inhibitor peptides arrest mammalian sperm motility. J.Biol.Chem. 272 4747 PMID: 9030527

Carr et al (1992) Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain. J.Biol.Chem. 267 13376 PMID: 1618839

Stival et al (2018) Disruption of protein kinase A localization induces acrosomal exocytosis in capacitated mouse sperm. J.Biol.Chem. 293 9435 PMID: 29700114

If you know of a relevant reference for st-Ht31, please let us know.

Keywords: st-Ht31, st-Ht31 supplier, st_Ht31, st, Ht, 31, stearated, A-kinase, anchoring, protein, AKAP, cAMP-dependent, PKA, scaffolding, proteins, Protein, Kinase, A, A-kinase-anchoring, protiens, 6286, Tocris Bioscience

2 Citations for st-Ht31

Citations are publications that use Tocris products. Selected citations for st-Ht31 include:

Martin E et al (2020) TGFβ1 Induces Axonal Outgrowth via ALK5/PKA/SMURF1-Mediated Degradation of RhoA and Stabilization of PAR6. Eneuro 7 PMID: 32887692

G Stanley et al (2022) Mislocalization of protein kinase A drives pathology in Cushing's syndrome. Cell Rep 40 111073 PMID: 35830806

Do you know of a great paper that uses st-Ht31 from Tocris? Please let us know.

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