cAMPS-Sp, triethylammonium salt

Pricing Availability   Qty
Description: Cell-permeable cAMP analog
Chemical Name: (S)-Adenosine, cyclic 3',5'-(hydrogenphosphorothioate) triethylammonium
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity for cAMPS-Sp, triethylammonium salt

cAMPS-Sp, triethylammonium salt is a cell-permeable cAMP analog that activates cAMP receptor proteins such as PKA and cAMP-regulated guanine nucleotide exchange factor.

R-enantiomer also available.

Technical Data for cAMPS-Sp, triethylammonium salt

M. Wt 446.46
Formula C10H12N5O5PS.C6H15N
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 93602-66-5
PubChem ID 57369926
Smiles [H][C@@]([C@@](O[C@@H](N3C=NC4=C3N=CN=C4N)[C@@H]2O)([H])CO1)2O[P@]1([S-])=O.CC[NH+](CC)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for cAMPS-Sp, triethylammonium salt

Solvent Max Conc. mg/mL Max Conc. mM
water 44.65 100

Preparing Stock Solutions for cAMPS-Sp, triethylammonium salt

The following data is based on the product molecular weight 446.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.24 mL 11.2 mL 22.4 mL
5 mM 0.45 mL 2.24 mL 4.48 mL
10 mM 0.22 mL 1.12 mL 2.24 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Datasheets for cAMPS-Sp, triethylammonium salt

Certificate of Analysis / Product Datasheet
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References for cAMPS-Sp, triethylammonium salt

References are publications that support the biological activity of the product.

Dostmann et al (1990) Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J.Biol.Chem. 265 10484 PMID: 2162349

Kawasaki et al (1998) A family of cAMP-binding proteins that directly activate Rap1. Science 282 2275 PMID: 9856955

Lin et al (2006) Ethanol inhibition of NMDA-induced responses and actute tolerance to the inhibition in rat rostral ventrolateral medulla in vivo: Involvement of cAMP-dependent protein kinases. Neuropharmacology 51 747 PMID: 16806304

O'Brian et al (1982) A kinetic study of interactions of (Rp)- and (Sp)-adenosine cyclic 3',5'-phosphorothioates with type II bovine cardiac muscle adenosine cyclic 3',5'-phosphate dependent protein kinase. Biochemistry 21 4371 PMID: 6289880

If you know of a relevant reference for cAMPS-Sp, triethylammonium salt, please let us know.

Keywords: cAMPS-Sp, triethylammonium salt, cAMPS-Sp, triethylammonium salt supplier, Cell-permeable, cAMP, Cyclic, adenosines, Monophosphate, Protein, Kinase, A, 1333, Tocris Bioscience

2 Citations for cAMPS-Sp, triethylammonium salt

Citations are publications that use Tocris products. Selected citations for cAMPS-Sp, triethylammonium salt include:

Keng et al (2012) Dual regulation by ethanol of the inhibitory effects of KA on spinal NMDA-induced pressor responses in rats. J Biomed Sci 19 11 PMID: 22300389

Mishra et al (2018) Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming TAX Resistance in ER-positive Breast Cancer. Clin Cancer Res 24 1987 PMID: 29386221

Do you know of a great paper that uses cAMPS-Sp, triethylammonium salt from Tocris? Please let us know.

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