cAMPS-Sp, triethylammonium salt

Pricing Availability Delivery Time Qty
Cat.No. 1333 - cAMPS-Sp, triethylammonium salt | C10H12N5O5PS.C6H15N | CAS No. 93602-66-5
Description: Cell-permeable cAMP analog
Chemical Name: (S)-Adenosine, cyclic 3',5'-(hydrogenphosphorothioate) triethylammonium
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Cell-permeable cAMP analog that activates cAMP receptor proteins such as PKA and cAMP-regulated guanine nucleotide exchange factor. Enantiomer cAMPS-Rp, triethylammonium salt (Cat. No. 1337) also available.

Technical Data

M. Wt 446.46
Formula C10H12N5O5PS.C6H15N
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 93602-66-5
PubChem ID 57369926
InChI Key OXIPZMKSNMRTIV-UHFFFAOYSA-N
Smiles [H][C@@]([C@@](O[C@@H](N3C=NC4=C3N=CN=C4N)[C@@H]2O)([H])CO1)2O[P@]1([S-])=O.CC[NH+](CC)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 44.65 100

Preparing Stock Solutions

The following data is based on the product molecular weight 446.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.24 mL 11.2 mL 22.4 mL
5 mM 0.45 mL 2.24 mL 4.48 mL
10 mM 0.22 mL 1.12 mL 2.24 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Dostmann et al (1990) Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J.Biol.Chem. 265 10484 PMID: 2162349

Kawasaki et al (1998) A family of cAMP-binding proteins that directly activate Rap1. Science 282 2275 PMID: 9856955

Lin et al (2006) Ethanol inhibition of NMDA-induced responses and actute tolerance to the inhibition in rat rostral ventrolateral medulla in vivo: Involvement of cAMP-dependent protein kinases. Neuropharmacology 51 747 PMID: 16806304

O'Brian et al (1982) A kinetic study of interactions of (Rp)- and (Sp)-adenosine cyclic 3',5'-phosphorothioates with type II bovine cardiac muscle adenosine cyclic 3',5'-phosphate dependent protein kinase. Biochemistry 21 4371 PMID: 6289880


If you know of a relevant reference for cAMPS-Sp, triethylammonium salt, please let us know.

Keywords: Cell-permeable cAMP Cyclic adenosines Monophosphate cAMP

1 Citation for cAMPS-Sp, triethylammonium salt

Citations are publications that use Tocris products. Selected citations for cAMPS-Sp, triethylammonium salt include:

Keng et al (2012) Dual regulation by ethanol of the inhibitory effects of ketamine on spinal NMDA-induced pressor responses in rats. J Biomed Sci 19 11 PMID: 22300389


Do you know of a great paper that uses cAMPS-Sp, triethylammonium salt from Tocris? If so please let us know.

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Cancer

Cancer Research Product Guide

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