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8-Bromo-cAMP, sodium salt
Cell-permeable cAMP analog; activator of protein kinase A.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 430.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.33 mL||11.63 mL||23.25 mL|
|5 mM||0.47 mL||2.33 mL||4.65 mL|
|10 mM||0.23 mL||1.16 mL||2.33 mL|
|50 mM||0.05 mL||0.23 mL||0.47 mL|
References are publications that support the biological activity of the product.
Carranza et al (1998) Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells. J.Physiol. 511 235 PMID: 9679177
Chow et al (1998) Functional modulation of P2X2 receptors by cyclic AMP-dependent protein kinase. J.Neurochem. 70 2606 PMID: 9603227
Hei et al (1991) Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs. Mol.Pharmacol. 39 233 PMID: 1847496
Wang et al (2011) A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells. Stem Cell Rev. 7 331 PMID: 21120637
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8 Citations for 8-Bromo-cAMP, sodium salt
Citations are publications that use Tocris products. Selected citations for 8-Bromo-cAMP, sodium salt include:
Goffin et al (2010) DA-dependent tuning of striatal inhibitory synaptogenesis. Br J Pharmacol 30 2935 PMID: 20181591
Nakao et al (2012) The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa. PLoS One 7 e32472 PMID: 22485131
Tozzi et al (2015) Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system. Front Cell Neurosci 9 192 PMID: 26074768
Adelfinger et al (2014) GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization. Biochem Pharmacol 91 369 PMID: 25065880
Niedenberger et al (2014) Actin dynamics regulate subcellular localization of PALLD in mouse Sertoli cells. Reproduction PMID: 24989903
Sergeant et al (2009) Spontaneous Ca2+ waves in rabbit corpus cavernosum: modulation by nitric oxide and cGMP. J.Sex.Med. 6 958 PMID: 19138373
Wang et al (2015) Astaxanthin protects steroidogenesis from hydrogen peroxide-induced oxidative stress in mouse Leydig cells. J Neurosci 13 1375 PMID: 25786065
Tuesta (2017) GLP-1 acts on habenular avoidance circuits to control nicotine intake. Nat Neurosci 20 708 PMID: 28368384
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HL-1 cardiomyocytes were treated with 100 nM fostriecin, 100 nM Okadaic acid or 50 nM 8-bromo-cAMP for 30 min followed by Western blot analysis for pCaMKII expression. 8-bromo-cAMP increased phosphorylation of CaMKII; indicating role of cAMP in CaMKII dephosphorylation.
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