8-Bromo-cAMP, sodium salt

Pricing Availability   Qty
Description: Cell-permeable cAMP analog
Chemical Name: 8-Bromoadenosine-3',5'-cyclic monophosphate sodium salt
Purity: ≥99% (HPLC)
Citations (8)
Reviews (1)
Literature (1)

Biological Activity for 8-Bromo-cAMP, sodium salt

8-Bromo-cAMP, sodium salt is a cell-permeable cAMP analog; activator of protein kinase A.

Compound Libraries for 8-Bromo-cAMP, sodium salt

8-Bromo-cAMP, sodium salt is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for 8-Bromo-cAMP, sodium salt

M. Wt 430.09
Formula C10H10BrN5NaO6P
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 76939-46-3
PubChem ID 23702958
Smiles [Na+].[H][C@@]12COP([O-])(=O)O[C@@]1([H])[C@@H](O)[C@@H](O2)N1C(Br)=NC2=C1N=CN=C2N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 8-Bromo-cAMP, sodium salt

Solvent Max Conc. mg/mL Max Conc. mM
water 43.01 100
DMSO 43.01 100

Preparing Stock Solutions for 8-Bromo-cAMP, sodium salt

The following data is based on the product molecular weight 430.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.63 mL 23.25 mL
5 mM 0.47 mL 2.33 mL 4.65 mL
10 mM 0.23 mL 1.16 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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Product Datasheets for 8-Bromo-cAMP, sodium salt

Certificate of Analysis / Product Datasheet
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References for 8-Bromo-cAMP, sodium salt

References are publications that support the biological activity of the product.

Carranza et al (1998) Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells. J.Physiol. 511 235 PMID: 9679177

Chow et al (1998) Functional modulation of P2X2 receptors by cyclic AMP-dependent protein kinase. J.Neurochem. 70 2606 PMID: 9603227

Hei et al (1991) Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs. Mol.Pharmacol. 39 233 PMID: 1847496

Wang et al (2011) A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells. Stem Cell Rev. 7 331 PMID: 21120637

If you know of a relevant reference for 8-Bromo-cAMP, sodium salt, please let us know.

Keywords: 8-Bromo-cAMP, sodium salt, 8-Bromo-cAMP, sodium salt supplier, Cell-permeable, cAMP, Membrane, permeable, analog, activates, activators, PKA, Cyclic, adenosines, Monophosphate, Inositol, Signaling, Signalling, Protein, Kinase, A, Kinases, 1140, Tocris Bioscience

8 Citations for 8-Bromo-cAMP, sodium salt

Citations are publications that use Tocris products. Selected citations for 8-Bromo-cAMP, sodium salt include:

Sergeant et al (2009) Spontaneous Ca2+ waves in rabbit corpus cavernosum: modulation by nitric oxide and cGMP. J.Sex.Med. 6 958 PMID: 19138373

Nakao et al (2012) The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa. PLoS One 7 e32472 PMID: 22485131

Tozzi et al (2015) Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system. Front Cell Neurosci 9 192 PMID: 26074768

Adelfinger et al (2014) GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization. Biochem Pharmacol 91 369 PMID: 25065880

Niedenberger et al (2014) Actin dynamics regulate subcellular localization of PALLD in mouse Sertoli cells. Reproduction PMID: 24989903

Goffin et al (2010) DA-dependent tuning of striatal inhibitory synaptogenesis. Br J Pharmacol 30 2935 PMID: 20181591

Tuesta (2017) GLP-1 acts on habenular avoidance circuits to control nicotine intake. Nat Neurosci 20 708 PMID: 28368384

Wang et al (2015) Astaxanthin protects steroidogenesis from hydrogen peroxide-induced oxidative stress in mouse Leydig cells. J Neurosci 13 1375 PMID: 25786065

Do you know of a great paper that uses 8-Bromo-cAMP, sodium salt from Tocris? Please let us know.

Reviews for 8-Bromo-cAMP, sodium salt

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8-bromo-cAMP phosphorylates cardiac CaMKII.
By Anonymous on 05/15/2019
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Cardiomyocytes

HL-1 cardiomyocytes were treated with 100 nM fostriecin, 100 nM Okadaic acid or 50 nM 8-bromo-cAMP for 30 min followed by Western blot analysis for pCaMKII expression. 8-bromo-cAMP increased phosphorylation of CaMKII; indicating role of cAMP in CaMKII dephosphorylation.

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