PKI 14-22 amide, myristoylated

Pricing Availability   Qty
Description: Cell-permeable protein kinase A inhibitor
Alternative Names: Protein kinase inhibitor-(14-22)-amide,myristoylated
Purity: ≥95% (HPLC)
Citations (16)
Reviews (1)

Biological Activity for PKI 14-22 amide, myristoylated

PKI 14-22 amide, myristoylated is a cell-permeable version of protein kinase inhibitor PKI (14-22) amide. The non-myristoylated version inhibits protein kinase A (Ki = 36 nM), inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1).

Technical Data for PKI 14-22 amide, myristoylated

M. Wt 1209.5
Formula C53H100N20O12

(Modifications: Gly-1 = Myr-Gly, Ile-9 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 201422-03-9
PubChem ID 71312213
Smiles [H]N(CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O)C(=O)CCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PKI 14-22 amide, myristoylated

Solubility Soluble to 1 mg/ml in DMSO

Product Datasheets for PKI 14-22 amide, myristoylated

Certificate of Analysis / Product Datasheet
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References for PKI 14-22 amide, myristoylated

References are publications that support the biological activity of the product.

Glass et al (1989) Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitory protein. J.Biol.Chem. 264 8802 PMID: 2722799

Zheng et al (2000) Activation of apolipoprotein AI gene expression by protein kinase A and kinase C through transcription factor, Sp1. J.Biol.Chem. 275 31747 PMID: 10829013

Farrow et al (2003) Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A. Surgery 134 197 PMID: 12947318

If you know of a relevant reference for PKI 14-22 amide, myristoylated, please let us know.

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16 Citations for PKI 14-22 amide, myristoylated

Citations are publications that use Tocris products. Selected citations for PKI 14-22 amide, myristoylated include:

Tseng et al (2010) PKA-induced receptor activator of NF-κB ligand (RANKL) expression in vascular cells mediates osteoclastogenesis but not matrix calcification. Autophagy 285 29925 PMID: 20663885

Muñoz-Llancao et al (2015) Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B. J Exp Med 35 11315 PMID: 26269639

Watson et al (2015) Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration. J Biol Chem 212 1021 PMID: 26101266

Singh et al (2015) The Orphan G Protein-Coupled Receptor Gpr175 (TPRA40) Enhances Hedgehog Signaling by Modulating cAMP Levels. J Biol Chem NULL PMID: 26451044

Okumura et al (2014) Phospholipase C-Related Catalytically Inactive Protein (PRIP) Regulates Lipolysis in Adipose Tissue by Modulating the Phosphorylation of Hormone-Sensitive Lipase. PLoS One 9 e100559 PMID: 24945349

Adelfinger et al (2014) GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization. Biochem Pharmacol 91 369 PMID: 25065880

Hashimotodani et al (2017) LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance. Neuron 95 928 PMID: 28817805

Maddugoda et al (2011) cAMP signaling by anthrax edema toxin induces transendothelial cell tunnels, which are resealed by MIM via Arp2/3-driven actin polymerization. Cell Host Microbe 10 464 PMID: 22100162

Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984 PMID: 21143600

Hamnett et al (2019) Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling. Nat Commun 10 542 PMID: 30710088

Jantarajit et al (2017) CFTR-mediated anion secretion across intestinal epithelium-like Caco-2 monolayer under PTH stimulation is dependent on intermediate conductance K+ channels. Am J Physiol Cell Physiol 313 C118 PMID: 28490422

Jakobsen et al (2019) Soluble adenylyl cyclase-mediated cAMP signaling and the putative role of PKA and EPAC in cerebral mitochondrial function. J Neurosci Res 97 1018 PMID: 31172581

Caiati et al (2013) PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus. J Neurosci 33 2973 PMID: 23407955

Al-Amily et al (2019) The functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic β-cell in rodent. Pflugers Arch 471 633 PMID: 30767071

Stival et al (2018) Disruption of protein kinase A localization induces acrosomal exocytosis in capacitated mouse sperm. J Biol Chem 293 9435 PMID: 29700114

Liu et al (2008) Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: pharmacologic approaches and functional recovery. Invest Ophthalmol Vis Sci 49 772 PMID: 18235027

Do you know of a great paper that uses PKI 14-22 amide, myristoylated from Tocris? Please let us know.

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Cyclic AMP Pathway-related studies.
Assay Type: In Vitro
Species: Human

PKI 14-22 amide, myristoylated was used in studies exploring the role of PKA in mediating drug-induced activation of the cyclic AMP pathway.