PKI (5-24)

Pricing Availability Delivery Time Qty
Cat.No. 6221 - PKI (5-24) | Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp | CAS No. 99534-03-9
Description: High affinity PKA inhibitor
Datasheet
Citations
Literature

Biological Activity

High affinity PKA inhibitor (Ki = 2.3 nM).

Technical Data

M. Wt 2222.4
Formula C94H148N32O31
Sequence TTYADFIASGRTGRRNAIHD
Storage Store at -20°C
CAS Number 99534-03-9
PubChem ID 102397230
InChI Key AXOXZJJMUVSZQY-LGGJAOENSA-N
Smiles [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2222.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.45 mL 2.25 mL 4.5 mL
5 mM 0.09 mL 0.45 mL 0.9 mL
10 mM 0.04 mL 0.22 mL 0.45 mL
50 mM 0.01 mL 0.04 mL 0.09 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Cheng et al (1986) A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. J.Biol.Chem. 261 989 PMID: 3511044

Narayana et al (1997) Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine. Biochemistry 36 4438 PMID: 9109651


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Keywords: PKI (5-24), supplier, High, affinity, PKA, inhibitor, Protein, Kinase, A, Protein, Kinase, A, Tocris Bioscience

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Citations are publications that use Tocris products.

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