PKI (5-24)

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Description: High affinity PKA inhibitor
Purity: ≥95% (HPLC)
Datasheet
Citations (3)
Reviews

Biological Activity for PKI (5-24)

PKI (5-24) is a high affinity PKA inhibitor (Ki = 2.3 nM).

Technical Data for PKI (5-24)

M. Wt 2222.4
Formula C94H148N32O31
Sequence TTYADFIASGRTGRRNAIHD
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 99534-03-9
PubChem ID 102397230
InChI Key AXOXZJJMUVSZQY-LGGJAOENSA-N
Smiles [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PKI (5-24)

Solubility Soluble to 1 mg/ml in water

Product Datasheets for PKI (5-24)

Certificate of Analysis / Product Datasheet
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References for PKI (5-24)

References are publications that support the biological activity of the product.

Cheng et al (1986) A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. J.Biol.Chem. 261 989 PMID: 3511044

Narayana et al (1997) Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine. Biochemistry 36 4438 PMID: 9109651


If you know of a relevant reference for PKI (5-24), please let us know.

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Keywords: PKI (5-24), PKI (5-24) supplier, High, affinity, PKA, inhibitor, Protein, Kinase, A, 6221, Tocris Bioscience

3 Citations for PKI (5-24)

Citations are publications that use Tocris products. Selected citations for PKI (5-24) include:

Fuqin et al (2022) HCN1 channels mediate mu opioid receptor long-term depression at insular cortex inputs to the dorsal striatum. J Physiol 600 4917-4938 PMID: 36181477

Ruihua et al (2020) Beta-adrenergic agonist protects retinal pigment epithelium against hydroxycholoroquine toxicity via cAMP-PKA signal pathway. Int J Ophthalmol 13 552-559 PMID: 32399404

Zhou et al (2013) Activation of β2-adrenoceptor enhances synaptic potentiation and behavioral memory via cAMP-PKA signaling in the medial prefrontal cortex of rats. Learn Mem 20 274 PMID: 23596314


Do you know of a great paper that uses PKI (5-24) from Tocris? Please let us know.

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