Rosiglitazone

Pricing Availability   Qty
Description: Potent and selective PPARγ agonist; antidiabetic agent
Alternative Names: BRL 49653
Chemical Name: 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
Purity: ≥98% (HPLC)
Datasheet
Citations (7)
Reviews (1)
Literature (4)

Biological Activity for Rosiglitazone

Rosiglitazone is a potent and selective PPARγ agonist (EC50 = 60 nM); exhibits no activity at PPARα and PPARβ. Promotes differentiation of pluripotent C3H10T1/2 stem cells into adipocytes. Also promotes differentiation of urothelial organoids in combination with Erlotinib (Cat. No. 7194). Exhibits antihyperglycemic activity in diabetic ob/ob mouse model. Antidiabetic agent.

Compound Libraries for Rosiglitazone

Rosiglitazone is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Rosiglitazone

M. Wt 357.43
Formula C18H19N3O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 122320-73-4
PubChem ID 77999
InChI Key YASAKCUCGLMORW-UHFFFAOYSA-N
Smiles CN(CCOC1=CC=C(CC2SC(NC2=O)=O)C=C1)C3=CC=CC=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Rosiglitazone

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.74 100

Preparing Stock Solutions for Rosiglitazone

The following data is based on the product molecular weight 357.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.8 mL 13.99 mL 27.98 mL
5 mM 0.56 mL 2.8 mL 5.6 mL
10 mM 0.28 mL 1.4 mL 2.8 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets for Rosiglitazone

Certificate of Analysis / Product Datasheet
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References for Rosiglitazone

References are publications that support the biological activity of the product.

Lehmann et al (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J.Biol.Chem. 270 12953 PMID: 7768881

Willson et al (1996) The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones. J.Med.Chem. 39 665 PMID: 8576907

Santos et al (2019) Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity. Nat.Commun. 10 4407 PMID: 31562298


If you know of a relevant reference for Rosiglitazone, please let us know.

View Related Products by Product Action

View all PPARγ Agonists

Keywords: Rosiglitazone, Rosiglitazone supplier, BRL49653, High, affinity, selective, PPAR, agonist, thiazolidinedione, TZD, derivative, antidiabetic, agent, organoids, differentiation, BRL, 49653, PPARgamma, Receptors, Other, Differentiation, Products, Organoids, 5325, Tocris Bioscience

7 Citations for Rosiglitazone

Citations are publications that use Tocris products. Selected citations for Rosiglitazone include:

Matsa et al (2016) Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro. Cell Stem Cell. 19 311 PMID: 27545504

Fellous et al (2020) Phytocannabinoids promote viability and functional adipogenesis of bone marrow-derived mesenchymal stem cells through different molecular targets Biochemical Pharmacology 175 PMID: 32061773

Smith et al (2019) Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties. Psychopharmacology (Berl) PMID: 31119329

Vitale et al (2018) Fishing for Targets of Alien Metabolites: A Novel Peroxisome Proliferator-Activated Receptor (PPAR) Agonist from a Marine Pest. Mar Drugs 16 PMID: 30400299


Do you know of a great paper that uses Rosiglitazone from Tocris? Please let us know.

Reviews for Rosiglitazone

Average Rating: 5 (Based on 1 Review.)

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Agonist dose-response analyses of the Human PPAR gamma Assay..
By GAJANAN KATKAR on 12/07/2019
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: PPARg reporter cells

PPAR gamma Assay was performed using manual dispensing and following the protocol described in this Technical Manual, using the Rosiglitazone. PPAR gamma reporter cells treated with 2,500 nM Rosiglitazone yielded an average RLU value with CV=7%, S/B = 162 and a corresponding Z’= 0.78.


Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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