Rosiglitazone

Pricing Availability Delivery Time Qty
Cat.No. 5325 - Rosiglitazone | C18H19N3O3S | CAS No. 122320-73-4
Description: Potent and selective PPARγ agonist; antidiabetic agent.
Alternative Names: BRL 49653
Chemical Name: 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Potent and selective PPARγ agonist (EC50 = 60 nM); exhibits no activity at PPARα and PPARβ. Promotes differentiation of pluripotent C3H10T1/2 stem cells into adipocytes. Exhibits antihyperglycemic activity in diabetic ob/ob mouse model. Antidiabetic agent.

Compound Libraries

Rosiglitazone is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 357.43
Formula C18H19N3O3S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 122320-73-4
PubChem ID 77999
InChI Key YASAKCUCGLMORW-UHFFFAOYSA-N
Smiles CN(CCOC1=CC=C(CC2SC(NC2=O)=O)C=C1)C3=CC=CC=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 35.74 100
DMSO 35.74 100

Preparing Stock Solutions

The following data is based on the product molecular weight 357.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.8 mL 13.99 mL 27.98 mL
5 mM 0.56 mL 2.8 mL 5.6 mL
10 mM 0.28 mL 1.4 mL 2.8 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lehmann et al (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J.Biol.Chem. 270 12953 PMID: 7768881

Willson et al (1996) The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones. J.Med.Chem. 39 665 PMID: 8576907


If you know of a relevant reference for Rosiglitazone, please let us know.

View Related Products by Product Action

View all PPARγ Agonists

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2 Citations for Rosiglitazone

Citations are publications that use Tocris products. Selected citations for Rosiglitazone include:

Matsa et al (2016) Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro. Cell Stem Cell. 19 311 PMID: 27545504

Ahlem et al (2011) Studies of the pharmacology of 17α-ethynyl-androst-5-ene-3β,7β,17β-triol, a synthetic anti-inflammatory androstene. Int J Clin Exp Med 4 119 PMID: 21686136


Do you know of a great paper that uses Rosiglitazone from Tocris? If so please let us know.

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Pathways for Rosiglitazone

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