Edaglitazone

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Description: Potent and selective PPARγ agonist; antidiabetic
Alternative Names: R 483,BM 131258
Chemical Name: 5-[[4-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethoxy]benzo[b]thien-7-yl]methyl]-2,4-thiazolidinedione
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity for Edaglitazone

Edaglitazone is a potent and selective PPARγ agonist (EC50 values are 35.6 and 1053 nM for PPARγ and PPARα cofactor recruitment respectively. Enhances insulin sensitivity in obese, but not lean, rats. Antidiabetic and orally bioavailable.

Compound Libraries for Edaglitazone

Edaglitazone is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Edaglitazone

M. Wt 464.56
Formula C24H20N2O4S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 213411-83-7
PubChem ID 9825701
InChI Key HAAXAFNSRADSMK-UHFFFAOYSA-N
Smiles CC(OC(C5=CC=CC=C5)=N4)=C4CCOC(C3=C2SC=C3)=CC=C2CC1C(NC(S1)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Edaglitazone

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100

Preparing Stock Solutions for Edaglitazone

The following data is based on the product molecular weight 464.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.76 mL 21.53 mL
5 mM 0.43 mL 2.15 mL 4.31 mL
10 mM 0.22 mL 1.08 mL 2.15 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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References for Edaglitazone

References are publications that support the biological activity of the product.

Fürnsinn et al (1999) Chronic and acute effects of thiazolidinediones BM13.1258 and BM15.2054 on rat skeletal muscle glucose metabolism. Br. J. Pharmacol. 128 1141 PMID: 10578125

Dietz et al (2012) Comparative molecular profiling of the PPARα/γ activator aleglitazar: PPAR selectivity, activity and interaction with cofactors. ChemMedChem 7 1101 PMID: 22489042


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Keywords: Edaglitazone, Edaglitazone supplier, potent, selective, peroxisome, proliferator-activated, receptors, PPARgamma, PPARg, PPARγ, agonists, diabetes, antidiabetics, R483, BM131258, insulin, sensitizers, R, 483, BM, 131258, Receptors, 4784, Tocris Bioscience

1 Citation for Edaglitazone

Citations are publications that use Tocris products. Selected citations for Edaglitazone include:

Hui et al (2022) An obesogenic feedforward loop involving PPARγ, acyl-CoA binding protein and GABAA receptor. Cell Death Dis 13 356 PMID: 35436993


Do you know of a great paper that uses Edaglitazone from Tocris? Please let us know.

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