Edaglitazone

Pricing Availability Delivery Time Qty
Cat.No. 4784 - Edaglitazone | C24H20N2O4S2 | CAS No. 213411-83-7
Description: Potent and selective PPARγ agonist; antidiabetic
Alternative Names: R 483, BM 131258
Chemical Name: 5-[[4-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethoxy]benzo[b]thien-7-yl]methyl]-2,4-thiazolidinedione
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective PPARγ agonist (EC50 values are 35.6 and 1053 nM for PPARγ and PPARα cofactor recruitment respectively. Enhances insulin sensitivity in obese, but not lean, rats. Antidiabetic and orally bioavailable.

Compound Libraries

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Technical Data

M. Wt 464.56
Formula C24H20N2O4S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 213411-83-7
PubChem ID 9825701
InChI Key HAAXAFNSRADSMK-UHFFFAOYSA-N
Smiles CC(OC(C5=CC=CC=C5)=N4)=C4CCOC(C3=C2SC=C3)=CC=C2CC1C(NC(S1)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 464.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.76 mL 21.53 mL
5 mM 0.43 mL 2.15 mL 4.31 mL
10 mM 0.22 mL 1.08 mL 2.15 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Fürnsinn et al (1999) Chronic and acute effects of thiazolidinediones BM13.1258 and BM15.2054 on rat skeletal muscle glucose metabolism. Br. J. Pharmacol. 128 1141 PMID: 10578125

Dietz et al (2012) Comparative molecular profiling of the PPARα/γ activator aleglitazar: PPAR selectivity, activity and interaction with cofactors. ChemMedChem 7 1101 PMID: 22489042


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Keywords: Edaglitazone, supplier, potent, selective, peroxisome, proliferator-activated, receptors, PPARgamma, PPARg, PPARγ, agonists, diabetes, antidiabetics, R483, BM131258, insulin, sensitizers, R, 483, BM, 131258, PPARgamma, Receptors, PPARgamma, Receptors, Tocris Bioscience

Citations for Edaglitazone

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