PPARδ

Peroxisome proliferator-activated receptor delta (PPARδ), also known as PPARβ, is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
2229 GW 0742
Highly selective, potent PPARδ agonist
5674 GW 501516
Potent and selective PPARδ agonist
1856 L-165,041
Potent PPARδ agonist

Antagonists

Cat No Product Name / Activity
4344 FH 535
PPARγ/δ antagonist; also inhibits Wnt/β-catenin signaling
3433 GSK 0660
Selective PPARδ antagonist
3961 GSK 3787
Potent and selective PPARδ antagonist

Peroxisome proliferator-activated receptor delta (PPARδ), also known as PPARβ, is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression.

PPARδ displays a ubiquitous expression pattern and is thought to regulate placental and gut development, fatty acid oxidation, adaptive thermogenesis, control of cell proliferation and differentiation and tissue repair. The human gene encoding PPARδ has been localized to chromosome 6 (6p21.2).

External sources of pharmacological information for PPARδ :

    Literature for PPARδ

    Cancer

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

    • Cancer Metabolism
    • Epigenetics in Cancer
    • Receptor Signaling
    • Cell Cycle and DNA Damage Repair
    • Angiogenesis
    • Invasion and Metastasis
    Cardiovascular

    Cardiovascular Research Product Guide

    A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

    • Hypertension
    • Thrombosis and Hemostasis
    • Atherosclerosis
    • Myocardial Infarction
    • Ischemia/Reperfusion Injury
    • Arrhythmias
    • Heart Failure
    Nuclear Receptors

    Nuclear Receptors Product Listing

    A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

    • Androgen Receptors
    • Estrogen Receptors
    • Retinoic Acid Receptors
    • Retinoid X Receptors
    • Vitamin D Receptors

    PPARδ Gene Data

    Species Gene Symbol Gene Accession No. Protein Accession No.
    Human PPARD NM_006238 Q03181
    Mouse Ppard NM_011145 P35396
    Rat Ppard NM_013141 Q62879