PPARδ

Peroxisome proliferator-activated receptor delta (PPARδ), also known as PPARβ, is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression.

Products
Background
Gene Data

PPARδ Agonists

Cat. No. Product Name / Activity
2229 GW 0742
Highly selective, potent PPARδ agonist
5674 GW 501516
Potent and selective PPARδ agonist
1856 L-165,041
Potent PPARδ agonist

PPARδ Antagonists

Cat. No. Product Name / Activity
4344 FH 535
PPARγ/δ antagonist; also inhibits Wnt/β-catenin signaling
3433 GSK 0660
Selective PPARδ antagonist
3961 GSK 3787
Potent and selective PPARδ antagonist

Peroxisome proliferator-activated receptor delta (PPARδ), also known as PPARβ, is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression.

PPARδ displays a ubiquitous expression pattern and is thought to regulate placental and gut development, fatty acid oxidation, adaptive thermogenesis, control of cell proliferation and differentiation and tissue repair. The human gene encoding PPARδ has been localized to chromosome 6 (6p21.2).

External sources of pharmacological information for PPARδ :

PPARδ Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human PPARD NM_006238 Q03181
Mouse Ppard NM_011145 P35396
Rat Ppard NM_013141 Q62879