GW 1929 hydrochloride

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Cat.No. 1664 - GW 1929 hydrochloride | C30H29N3O4.HCl | CAS No. 1217466-21-1
Description: Selective PPARγ agonist. Orally active
Chemical Name: N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (4)

Biological Activity

Highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist (pEC50 values are 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors respectively). Decreases glucose, fatty acid and triglyceride levels following oral administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M. Wt 532.03
Formula C30H29N3O4.HCl
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 1217466-21-1
PubChem ID 76453663
InChI Key KXNKIKXTGRMLEY-UHFFFAOYSA-N
Smiles Cl.CN(CCOC1=CC=C(C[C@H](NC2=CC=CC=C2C(=O)C2=CC=CC=C2)C(O)=O)C=C1)C1=NC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 49.56 100 with gentle warming
water 26.6 50

Preparing Stock Solutions

The following data is based on the product molecular weight 532.03. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.88 mL 9.4 mL 18.8 mL
5 mM 0.38 mL 1.88 mL 3.76 mL
10 mM 0.19 mL 0.94 mL 1.88 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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View all PPARγ Agonists

Keywords: GW 1929 hydrochloride, GW 1929 hydrochloride supplier, Selective, PPARγ, PPARgamma, agonists, orally, active, Peroxisome, Proliferator-activating, Receptors, PPAR, GW1929, hydrochloride, GlaxoSmithKline, GSK, 1664, Tocris Bioscience

2 Citations for GW 1929 hydrochloride

Citations are publications that use Tocris products. Selected citations for GW 1929 hydrochloride include:

Chai et al (2013) Nicotinic acid receptor GPR109A is down-regulated in human macrophage-derived foam cells. PLoS One 8 e62934 PMID: 23658787

Hatano et al (2010) Murine atopic dermatitis responds to peroxisome proliferator-activated receptors α and β/δ (but not γ) and liver X receptor activators. Endocrinology 125 160 PMID: 19818482


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Literature in this Area

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