GW 1929 hydrochloride

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Cat.No. 1664 - GW 1929 hydrochloride | C30H29N3O4.HCl | CAS No. 1217466-21-1
Description: Selective PPARγ agonist. Orally active
Chemical Name: N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist (pEC50 values are 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors respectively). Decreases glucose, fatty acid and triglyceride levels following oral administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M. Wt 532.03
Formula C30H29N3O4.HCl
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 1217466-21-1
PubChem ID 76453663
InChI Key KXNKIKXTGRMLEY-UHFFFAOYSA-N
Smiles Cl.CN(CCOC1=CC=C(C[C@H](NC2=CC=CC=C2C(=O)C2=CC=CC=C2)C(O)=O)C=C1)C1=NC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.56 100
ethanol 49.56 100mM with gentle warming
water 53.2 100

Preparing Stock Solutions

The following data is based on the product molecular weight 532.03. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.88 mL 9.4 mL 18.8 mL
5 mM 0.38 mL 1.88 mL 3.76 mL
10 mM 0.19 mL 0.94 mL 1.88 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Brown et al (1999) A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-γ reverses the diabetic phenotype of the Zucker diabetic fatty rat. Diabetes 48 1415 PMID: 10389847

Nugent et al (2001) Potentiation of glucose uptake in 3T3-L1 adipocytes by PPARγ agonists is maintained in cells expressing a PPARγ dominant-negative mutant: evidence for selectivity in the downstream responses to PPARγ activation. Mol.Endocrinol. 15 1729 PMID: 11579205

Way et al (2001) Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor γ agonists. J.Biol.Chem. 276 25651 PMID: 11373275


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Keywords: GW 1929 hydrochloride, supplier, Selective, PPARγ, PPARgamma, agonists, orally, active, Peroxisome, Proliferator-activating, Receptors, PPAR, GW1929, hydrochloride, GlaxoSmithKline, GSK, PPARgamma, Receptors, Tocris Bioscience

2 Citations for GW 1929 hydrochloride

Citations are publications that use Tocris products. Selected citations for GW 1929 hydrochloride include:

Hatano et al (2010) Murine atopic dermatitis responds to peroxisome proliferator-activated receptors α and β/δ (but not γ) and liver X receptor activators. Endocrinology 125 160 PMID: 19818482

Chai et al (2013) Nicotinic acid receptor GPR109A is down-regulated in human macrophage-derived foam cells. PLoS One 8 e62934 PMID: 23658787


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