Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewSR 16832
Description: Dual site PPARγ inhibitor
Chemical Name: 2-Chloro-N-(6-methoxy-4-quinolinyl)-5-nitrobenzamide
Purity: ≥98% (HPLC)
Biological Activity for SR 16832
SR 16832 is a dual site PPARγ inhibitor. Acts at orthosteric and allosteric sites in the ligand binding domain. Inhibits binding of endogenous ligands and transcriptional activity of PPARγ, more effectively than the orthosteric covalent antagonists GW 9662 (Cat. No. 1508) and T 0070907 (Cat. No. 2301).
Compound Libraries for SR 16832
SR 16832 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for SR 16832
| M. Wt | 357.75 |
| Formula | C17H12ClN3O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2088135-12-8 |
| PubChem ID | 134160241 |
| InChI Key | CVTZAGCRUDYUGB-UHFFFAOYSA-N |
| Smiles | COC1=CC2=C(N=CC=C2NC(C3=CC([N+]([O-])=O)=CC=C3Cl)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SR 16832
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.89 | 50 |
Preparing Stock Solutions for SR 16832
The following data is based on the product molecular weight 357.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.59 mL | 27.95 mL | 55.9 mL |
| 2.5 mM | 1.12 mL | 5.59 mL | 11.18 mL |
| 5 mM | 0.56 mL | 2.8 mL | 5.59 mL |
| 25 mM | 0.11 mL | 0.56 mL | 1.12 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for SR 16832
References for SR 16832
References are publications that support the biological activity of the product.
Brust et al (2017) Modification of the othosteric PPARγ covalent antagonist scaffold yields an improved dual-site allosteric inhibitor. ACS Chem.Biol. 12 969 PMID: 28165718
If you know of a relevant reference for SR 16832, please let us know.
View Related Products by Product Action
Keywords: SR 16832, SR 16832 supplier, SR16832, PPAR, gamma, peroxisome, proliferator, activated, receptor, inhibitors, inhibits, PPARgamma, Receptors, 6383, Tocris Bioscience
Citations for SR 16832
Citations are publications that use Tocris products.
Currently there are no citations for SR 16832. Do you know of a great paper that uses SR 16832 from Tocris? Please let us know.
Reviews for SR 16832
There are currently no reviews for this product. Be the first to review SR 16832 and earn rewards!
Have you used SR 16832?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Cardiovascular Research Product Guide
A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:
- Hypertension
- Thrombosis and Hemostasis
- Atherosclerosis
- Myocardial Infarction
- Ischemia/Reperfusion Injury
- Arrhythmias
- Heart Failure
Nuclear Receptors Product Listing
A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:
- Androgen Receptors
- Estrogen Receptors
- Retinoic Acid Receptors
- Retinoid X Receptors
- Vitamin D Receptors
Epilepsy Poster
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.