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Biological Activity for SR 16832
SR 16832 is a dual site PPARγ inhibitor. Acts at orthosteric and allosteric sites in the ligand binding domain. Inhibits binding of endogenous ligands and transcriptional activity of PPARγ, more effectively than the orthosteric covalent antagonists GW 9662 (Cat. No. 1508) and T 0070907 (Cat. No. 2301).
Compound Libraries for SR 16832
Technical Data for SR 16832
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SR 16832
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SR 16832
The following data is based on the product molecular weight 357.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.59 mL||27.95 mL||55.9 mL|
|2.5 mM||1.12 mL||5.59 mL||11.18 mL|
|5 mM||0.56 mL||2.8 mL||5.59 mL|
|25 mM||0.11 mL||0.56 mL||1.12 mL|
References for SR 16832
References are publications that support the biological activity of the product.
Brust et al (2017) Modification of the othosteric PPARγ covalent antagonist scaffold yields an improved dual-site allosteric inhibitor. ACS Chem.Biol. 12 969 PMID: 28165718
If you know of a relevant reference for SR 16832, please let us know.
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Keywords: SR 16832, SR 16832 supplier, SR16832, PPAR, gamma, peroxisome, proliferator, activated, receptor, inhibitors, inhibits, PPARgamma, Receptors, 6383, Tocris Bioscience
Citations for SR 16832
Citations are publications that use Tocris products.
Currently there are no citations for SR 16832. Do you know of a great paper that uses SR 16832 from Tocris? Please let us know.
Reviews for SR 16832
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.