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Description: Dual site PPARγ inhibitor
Chemical Name: 2-Chloro-N-(6-methoxy-4-quinolinyl)-5-nitrobenzamide
Purity: ≥98% (HPLC)
Biological Activity for SR 16832
SR 16832 is a dual site PPARγ inhibitor. Acts at orthosteric and allosteric sites in the ligand binding domain. Inhibits binding of endogenous ligands and transcriptional activity of PPARγ, more effectively than the orthosteric covalent antagonists GW 9662 (Cat. No. 1508) and T 0070907 (Cat. No. 2301).
Compound Libraries for SR 16832
SR 16832 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for SR 16832
| M. Wt | 357.75 |
| Formula | C17H12ClN3O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2088135-12-8 |
| PubChem ID | 134160241 |
| InChI Key | CVTZAGCRUDYUGB-UHFFFAOYSA-N |
| Smiles | COC1=CC2=C(N=CC=C2NC(C3=CC([N+]([O-])=O)=CC=C3Cl)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SR 16832
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.89 | 50 |
Preparing Stock Solutions for SR 16832
The following data is based on the product molecular weight 357.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.59 mL | 27.95 mL | 55.9 mL |
| 2.5 mM | 1.12 mL | 5.59 mL | 11.18 mL |
| 5 mM | 0.56 mL | 2.8 mL | 5.59 mL |
| 25 mM | 0.11 mL | 0.56 mL | 1.12 mL |
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Product Datasheets for SR 16832
References for SR 16832
References are publications that support the biological activity of the product.
Brust et al (2017) Modification of the othosteric PPARγ covalent antagonist scaffold yields an improved dual-site allosteric inhibitor. ACS Chem.Biol. 12 969 PMID: 28165718
If you know of a relevant reference for SR 16832, please let us know.
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Keywords: SR 16832, SR 16832 supplier, SR16832, PPAR, gamma, peroxisome, proliferator, activated, receptor, inhibitors, inhibits, PPARgamma, Receptors, 6383, Tocris Bioscience
2 Citations for SR 16832
Citations are publications that use Tocris products. Selected citations for SR 16832 include:
Christine et al (2020) Lipid metabolism adaptations are reduced in human compared to murine Schwann cells following injury. Nat Commun 11 2123 PMID: 32358558
Clary B et al (2021) SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis. Cell Rep 36 109345 PMID: 34260923
Do you know of a great paper that uses SR 16832 from Tocris? Please let us know.
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