Home / Pharmacology / Nuclear Receptors / PPARs / PPARγ / PPARγ Partial Agonists / INT 131

INT 131

Cat. No. 7423 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: PPARγ partial agonist
Chemical Name: 2,4-Dichloro-N-[3,5-dichloro-4-(3-quinolinyloxy)phenyl]benzenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for INT 131

INT 131 is a potent and selective PPARγ partial agonist (EC50 = 4 nM; Ki = 3.7 nM). It has a 20-fold higher affinity for PPARγ compared with that of Rosiglitazone (Cat. No. 5325). INT 131 improves glucose tolerance in a rodent model of diabetes without inducing hemodynamic and cardiovascular effects. Antidiabetic agent.

Technical Data for INT 131

M. Wt 514.21
Formula C21H12Cl4N2O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 315224-26-1
PubChem ID 10229498
InChI Key NMRWDFUZLLQSBN-UHFFFAOYSA-N
Smiles O=S(=O)(NC1=CC(Cl)=C(OC2=CN=C3C=CC=CC3=C2)C(Cl)=C1)C4=CC=C(Cl)C=C4Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for INT 131

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.57 5
ethanol 2.57 5

Preparing Stock Solutions for INT 131

The following data is based on the product molecular weight 514.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 38.89 mL 194.47 mL 388.95 mL
0.25 mM 7.78 mL 38.89 mL 77.79 mL
0.5 mM 3.89 mL 19.45 mL 38.89 mL
2.5 mM 0.78 mL 3.89 mL 7.78 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for INT 131

References are publications that support the biological activity of the product.

Frkic et al (2017) Structure-activity relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) analogs for PPARγ-targeted antidiabetics. J.Med.Chem. 60 4584 PMID: 28485590

Motani et al (2009) INT131: a selective modulator of PPARγ. J.Mol.Biol. 386 1301 PMID: 19452630

If you know of a relevant reference for INT 131, please let us know.

View Related Products by Target

View Related Products by Product Action

View all PPARγ Partial Agonists

Keywords: INT 131, INT 131 supplier, INT131, PPARγ, PPARgamma, partial, agonists, antidiabetics, agent, Peroxisome, Proliferator-activating, Receptors, in, vivo, diabetes, 7423, Tocris Bioscience

Citations for INT 131

Citations are publications that use Tocris products.

Currently there are no citations for INT 131. Do you know of a great paper that uses INT 131 from Tocris? Please let us know.

Reviews for INT 131

There are currently no reviews for this product. Be the first to review INT 131 and earn rewards!

Have you used INT 131?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review