INT 131

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Description: PPARγ partial agonist
Chemical Name: 2,4-Dichloro-N-[3,5-dichloro-4-(3-quinolinyloxy)phenyl]benzenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity for INT 131

INT 131 is a potent and selective PPARγ partial agonist (EC50 = 4 nM; Ki = 3.7 nM). It has a 20-fold higher affinity for PPARγ compared with that of Rosiglitazone (Cat. No. 5325). INT 131 improves glucose tolerance in a rodent model of diabetes without inducing hemodynamic and cardiovascular effects. Antidiabetic agent.

Technical Data for INT 131

M. Wt 514.21
Formula C21H12Cl4N2O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 315224-26-1
PubChem ID 10229498
InChI Key NMRWDFUZLLQSBN-UHFFFAOYSA-N
Smiles O=S(=O)(NC1=CC(Cl)=C(OC2=CN=C3C=CC=CC3=C2)C(Cl)=C1)C4=CC=C(Cl)C=C4Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for INT 131

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.57 5
ethanol 2.57 5

Preparing Stock Solutions for INT 131

The following data is based on the product molecular weight 514.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 38.89 mL 194.47 mL 388.95 mL
0.25 mM 7.78 mL 38.89 mL 77.79 mL
0.5 mM 3.89 mL 19.45 mL 38.89 mL
2.5 mM 0.78 mL 3.89 mL 7.78 mL

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References for INT 131

References are publications that support the biological activity of the product.

Frkic et al (2017) Structure-activity relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) analogs for PPARγ-targeted antidiabetics. J.Med.Chem. 60 4584 PMID: 28485590

Motani et al (2009) INT131: a selective modulator of PPARγ. J.Mol.Biol. 386 1301 PMID: 19452630


If you know of a relevant reference for INT 131, please let us know.

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Keywords: INT 131, INT 131 supplier, INT131, PPARγ, PPARgamma, partial, agonists, antidiabetics, agent, Peroxisome, Proliferator-activating, Receptors, in, vivo, diabetes, 7423, Tocris Bioscience

Citations for INT 131

Citations are publications that use Tocris products.

Currently there are no citations for INT 131. Do you know of a great paper that uses INT 131 from Tocris? Please let us know.

Reviews for INT 131

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Literature in this Area

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