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Submit ReviewINT 131
Description: PPARγ partial agonist
Chemical Name: 2,4-Dichloro-N-[3,5-dichloro-4-(3-quinolinyloxy)phenyl]benzenesulfonamide
Purity: ≥98% (HPLC)
Biological Activity for INT 131
INT 131 is a potent and selective PPARγ partial agonist (EC50 = 4 nM; Ki = 3.7 nM). It has a 20-fold higher affinity for PPARγ compared with that of Rosiglitazone (Cat. No. 5325). INT 131 improves glucose tolerance in a rodent model of diabetes without inducing hemodynamic and cardiovascular effects. Antidiabetic agent.
Technical Data for INT 131
| M. Wt | 514.21 |
| Formula | C21H12Cl4N2O3S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 315224-26-1 |
| PubChem ID | 10229498 |
| InChI Key | NMRWDFUZLLQSBN-UHFFFAOYSA-N |
| Smiles | O=S(=O)(NC1=CC(Cl)=C(OC2=CN=C3C=CC=CC3=C2)C(Cl)=C1)C4=CC=C(Cl)C=C4Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for INT 131
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.57 | 5 | |
| ethanol | 2.57 | 5 |
Preparing Stock Solutions for INT 131
The following data is based on the product molecular weight 514.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 38.89 mL | 194.47 mL | 388.95 mL |
| 0.25 mM | 7.78 mL | 38.89 mL | 77.79 mL |
| 0.5 mM | 3.89 mL | 19.45 mL | 38.89 mL |
| 2.5 mM | 0.78 mL | 3.89 mL | 7.78 mL |
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Product Datasheets for INT 131
References for INT 131
References are publications that support the biological activity of the product.
Frkic et al (2017) Structure-activity relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) analogs for PPARγ-targeted antidiabetics. J.Med.Chem. 60 4584 PMID: 28485590
Motani et al (2009) INT131: a selective modulator of PPARγ. J.Mol.Biol. 386 1301 PMID: 19452630
If you know of a relevant reference for INT 131, please let us know.
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Keywords: INT 131, INT 131 supplier, INT131, PPARγ, PPARgamma, partial, agonists, antidiabetics, agent, Peroxisome, Proliferator-activating, Receptors, in, vivo, diabetes, 7423, Tocris Bioscience
Citations for INT 131
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