PPARα

Peroxisome proliferator-activated receptor alpha (PPARα) is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
4190 CP 775146
Selective, high affinity PPARα agonist
4113 Fenofibrate
PPARα agonist
1677 GW 7647
Highly selective, potent PPARα agonist. Orally active
1484 Oleylethanolamide
PPARα agonist; also GPR55 agonist
0879 Palmitoylethanolamide
Endogenous lipid with PPARα agonist activity
1312 WY 14643
Selective PPARα agonist

Antagonists

Cat No Product Name / Activity
4618 GW 6471
PPARα antagonist
1311 MK 886
PPARα antagonist. Also FLAP inhibitor

Peroxisome proliferator-activated receptor alpha (PPARα) is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression. PPARα is located primarily in the liver, adipose tissue, kidney, heart, skeletal muscle and large intestine where it is thought to regulate fatty acid synthesis and oxidation, gluconeogenesis, ketogenesis and lipoprotein assembly. The human gene encoding PPARα has been localized to chromosome 22 (22q12-13.1).

External sources of pharmacological information for PPARα :

    Literature for PPARα

    Cancer

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

    • Cancer Metabolism
    • Epigenetics in Cancer
    • Receptor Signaling
    • Cell Cycle and DNA Damage Repair
    • Angiogenesis
    • Invasion and Metastasis
    Cardiovascular

    Cardiovascular Research Product Guide

    A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

    • Hypertension
    • Thrombosis and Hemostasis
    • Atherosclerosis
    • Myocardial Infarction
    • Ischemia/Reperfusion Injury
    • Arrhythmias
    • Heart Failure
    Nuclear Receptors

    Nuclear Receptors Product Listing

    A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

    • Androgen Receptors
    • Estrogen Receptors
    • Retinoic Acid Receptors
    • Retinoid X Receptors
    • Vitamin D Receptors

    PPARα Gene Data

    Species Gene Symbol Gene Accession No. Protein Accession No.
    Human PPARA NM_001001928 Q07869
    Mouse Ppara NM_011144 P23204
    Rat Ppara NM_013196 P37230