PPARα

Peroxisome proliferator-activated receptor alpha (PPARα) is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression.

Products
Background
Gene Data

Agonists

Cat No Product Name / Activity
4190 CP 775146
Selective, high affinity PPARα agonist
4113 Fenofibrate
PPARα agonist
1677 GW 7647
Highly selective, potent PPARα agonist. Orally active
1484 Oleylethanolamide
PPARα agonist; also GPR55 agonist
0879 Palmitoylethanolamide
Endogenous lipid with PPARα agonist activity
1312 WY 14643
Selective PPARα agonist

Antagonists

Cat No Product Name / Activity
4618 GW 6471
PPARα antagonist
1311 MK 886
PPARα antagonist. Also FLAP inhibitor

Peroxisome proliferator-activated receptor alpha (PPARα) is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression. PPARα is located primarily in the liver, adipose tissue, kidney, heart, skeletal muscle and large intestine where it is thought to regulate fatty acid synthesis and oxidation, gluconeogenesis, ketogenesis and lipoprotein assembly. The human gene encoding PPARα has been localized to chromosome 22 (22q12-13.1).

External sources of pharmacological information for PPARα :

    PPARα Gene Data

    Species Gene Symbol Gene Accession No. Protein Accession No.
    Human PPARA NM_001001928 Q07869
    Mouse Ppara NM_011144 P23204
    Rat Ppara NM_013196 P37230