T 0070907

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Description: Highly potent and selective covalent PPARγ antagonist
Chemical Name: 2-Chloro-5-nitro-N-4-pyridinylbenzamide
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Reviews (1)

Biological Activity for T 0070907

T 0070907 is a potent and selective irreversible PPARγ antagonist (IC50 = 1 nM). Displays > 800-fold selectivity for PPARγ over PPARα and PPARδ. Blocks transcriptional activity of PPARγ in vitro and inhibits Rosiglitazone-induced adipogenesis.

Compound Libraries for T 0070907

T 0070907 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for T 0070907

M. Wt 277.67
Formula C12H8N3O3Cl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 313516-66-4
PubChem ID 2777391
InChI Key FRPJSHKMZHWJBE-UHFFFAOYSA-N
Smiles [O-][N+](=O)C1=CC=C(Cl)C(=C1)C(=O)NC1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for T 0070907

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 27.77 100
DMSO 27.8 100

Preparing Stock Solutions for T 0070907

The following data is based on the product molecular weight 277.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.6 mL 18.01 mL 36.01 mL
5 mM 0.72 mL 3.6 mL 7.2 mL
10 mM 0.36 mL 1.8 mL 3.6 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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References for T 0070907

References are publications that support the biological activity of the product.

Lee et al (2002) T0070907, a selective ligand for peroxisome proliferator-activated receptor γ, functions as an antagonist of biochemical and cellular activities. J.Biol.Chem. 277 19649 PMID: 11877444

Rockwell and Kaminski (2004) A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes. J.Pharmacol.Exp.Ther. 311 683 PMID: 15284281

Schaefer et al (2005) Peroxisome proliferator-activated receptor γ inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells. Cancer Res. 65 2251 PMID: 15781638


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Keywords: T 0070907, T 0070907 supplier, potent, selective, PPARγ, PPARgamma, antagonists, Peroxisome, Proliferator-activating, Receptors, T0070907, 2301, Tocris Bioscience

Reviews for T 0070907

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T 0070907 inhibits 15d-PGJ2-induced ERK activation in cardiomyocytes.
By Chintan Koyani on 12/10/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: HL-1 cardiomyocytes

HL-1 cardiomyocytes were incubated with T 0070907 (1 µM) for 30 min prior to addition of 15 µM 15d-PGJ2 for 30 min. Preincubation of cells with T 0070907 completely abolished activation of p42/44 MAPK indicating involvement of PPAR gamma in cellular signalling in response to 15d-PGJ2.

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