McN-A 343

Pricing Availability   Qty
Description: Selective M1 muscarinic agonist
Chemical Name: 4-[[[(3-Chlorophenyl)amino]carbonyl]oxy]-N,N,N-trimethyl-2-butyn-1-aminium chloride
Purity: ≥99% (HPLC)
Citations (2)
Literature (1)

Biological Activity for McN-A 343

McN-A 343 is a selective muscarinic M1 receptor agonist. Selectivity for M1 over other muscarinic receptor types appears to arise from a high efficacy at M1 receptors.

Technical Data for McN-A 343

M. Wt 317.21
Formula C14H18Cl2N2O2
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 55-45-8
PubChem ID 5926
Smiles ClC1=CC=CC(NC(OCC#CC[N+](C)(C)C)=O)=C1.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for McN-A 343

Solvent Max Conc. mg/mL Max Conc. mM
water 31.72 100

Preparing Stock Solutions for McN-A 343

The following data is based on the product molecular weight 317.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.15 mL 15.76 mL 31.52 mL
5 mM 0.63 mL 3.15 mL 6.3 mL
10 mM 0.32 mL 1.58 mL 3.15 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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Product Datasheets for McN-A 343

Certificate of Analysis / Product Datasheet
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References for McN-A 343

References are publications that support the biological activity of the product.

Davies et al (2001) Inhibition of field stimulation-induced contractions of rabbit vas deferens by muscarinic receptor agonists: selectivity of McN-A-343 for M1 receptors. J.Pharm.Pharmacol. 53 487 PMID: 11341365

Eglen et al (1996) Muscarinic receptor subtypes and smooth muscle function. Pharmacol.Rev. 48 531 PMID: 8981565

Micheletti and Schiavone (1990) Functional determination of McN-A-343 affinity for M1 muscarinic receptors. J.Pharmacol.Exp.Ther. 253 310 PMID: 1691785

If you know of a relevant reference for McN-A 343, please let us know.

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Keywords: McN-A 343, McN-A 343 supplier, Selective, M1, muscarinic, agonists, Receptors, Acetylcholine, ACh, McNA343, 1384, Tocris Bioscience

2 Citations for McN-A 343

Citations are publications that use Tocris products. Selected citations for McN-A 343 include:

Park et al (2013) Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging. Korean J Anesthesiol 38 1426 PMID: 23389690

Deng et al (2013) Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors. J Pharmacol Toxicol Methods 68 323 PMID: 23933114

Do you know of a great paper that uses McN-A 343 from Tocris? Please let us know.

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Literature in this Area

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