Xanomeline oxalate

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Cat.No. 3569 - Xanomeline oxalate | C14H23N3OS.C2H2O4 | CAS No. 141064-23-5
Description: Functionally selective M1 agonist
Chemical Name: 3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridine oxalate
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Functionally selective muscarinic M1 receptor agonist (EC50 values are 0.3, 5, 42, 52 and 92.5 nM at M1, M3, M5, M4 and M2 receptors respectively). Displays a complex pharmacological profile: reversible and wash-resistant binding, resulting in full agonist activity at M1; delayed wash-resistant partial agonist activity at M2; and delayed wash-resistant full agonist activity at M4. Exhibits antipsychotic activity, and improves cognitive deficits and behavioral disturbances in Alzheimer's disease and schizophrenia.

Compound Libraries

Xanomeline oxalate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 371.46
Formula C14H23N3OS.C2H2O4
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 141064-23-5
PubChem ID 18920248
InChI Key ZJOUESNWCLASJP-UHFFFAOYSA-N
Smiles CCCCCCOC1=NSN=C1C2=CCCN(C)C2.OC(C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.15 100
ethanol 9.29 25
water 3.71 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 371.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.46 mL 26.92 mL
5 mM 0.54 mL 2.69 mL 5.38 mL
10 mM 0.27 mL 1.35 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Jakubik et al (2008) Importance and prospects for design of selective muscarinic agonists. Physiol.Res. 57 S39 PMID: 18481916

Heinrich et al (2009) Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists. Eur.J.Pharmacol. 605 53 PMID: 19168056

Stanhope et al (2001) The muscarinic receptor agonist xanomeline has an antipsychotic-like profile in the rat. J.Pharmacol.Exp.Ther. 299 782 PMID:


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Keywords: Xanomeline oxalate, supplier, Functionally, selective, M1, agonists, Muscarinic, Receptors, Acetylcholine, ACh, M1, Receptors, Tocris Bioscience

1 Citation for Xanomeline oxalate

Citations are publications that use Tocris products. Selected citations for Xanomeline oxalate include:

Tian et al (2016) STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit Scientific Reports 6 36684  PMID: 27857196


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