Xanomeline oxalate

Pricing Availability   Qty
Description: Functionally selective M1 agonist
Chemical Name: 3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridine oxalate
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (5)

Biological Activity for Xanomeline oxalate

Xanomeline oxalate is a functionally selective muscarinic M1 receptor agonist (EC50 values are 0.3, 5, 42, 52 and 92.5 nM at M1, M3, M5, M4 and M2 receptors respectively). Displays a complex pharmacological profile: reversible and wash-resistant binding, resulting in full agonist activity at M1; delayed wash-resistant partial agonist activity at M2; and delayed wash-resistant full agonist activity at M4. Exhibits antipsychotic activity, and improves cognitive deficits and behavioral disturbances in Alzheimer's disease and schizophrenia.

Compound Libraries for Xanomeline oxalate

Xanomeline oxalate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Xanomeline oxalate

M. Wt 371.46
Formula C14H23N3OS.C2H2O4
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 141064-23-5
PubChem ID 18920248
InChI Key ZJOUESNWCLASJP-UHFFFAOYSA-N
Smiles CCCCCCOC1=NSN=C1C2=CCCN(C)C2.OC(C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Xanomeline oxalate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 3.71 10 with gentle warming
DMSO 37.15 100

Preparing Stock Solutions for Xanomeline oxalate

The following data is based on the product molecular weight 371.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.46 mL 26.92 mL
5 mM 0.54 mL 2.69 mL 5.38 mL
10 mM 0.27 mL 1.35 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets for Xanomeline oxalate

Certificate of Analysis / Product Datasheet
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References for Xanomeline oxalate

References are publications that support the biological activity of the product.

Jakubik et al (2008) Importance and prospects for design of selective muscarinic agonists. Physiol.Res. 57 S39 PMID: 18481916

Heinrich et al (2009) Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists. Eur.J.Pharmacol. 605 53 PMID: 19168056

Stanhope et al (2001) The muscarinic receptor agonist xanomeline has an antipsychotic-like profile in the rat. J.Pharmacol.Exp.Ther. 299 782 PMID: 11602695


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Keywords: Xanomeline oxalate, Xanomeline oxalate supplier, Functionally, selective, M1, agonists, Muscarinic, Receptors, Acetylcholine, ACh, 3569, Tocris Bioscience

1 Citation for Xanomeline oxalate

Citations are publications that use Tocris products. Selected citations for Xanomeline oxalate include:

Tian et al (2016) STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit Scientific Reports 6 36684 PMID: 27857196


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Literature in this Area

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Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.

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Cardiovascular Poster

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Learning & Memory Poster

Learning & Memory Poster

Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.

Schizophrenia Poster

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.