Chloride channels are a family of anion-selective channels involved in a diverse range of biological processes including the regulation of the excitability of neurons, skeletal, cardiac and smooth muscle, cell volume regulation, transepithelial salt transport, the acidification of intra- and extracellular compartments.
There are five main subtypes of chloride channels:
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Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
---|---|---|---|---|
ClC-1 | Human | CLCN1 | NM_000083 | P35523 |
Mouse | Clcn1 | NM_013491 | Q64347 | |
Rat | Clcn1 | NM_013147 | Q7TT77 | |
ClC-2 | Human | CLCN2 | NM_004366 | P51788 |
Mouse | Clcn2 | NM_009900 | Q9R0A1 | |
Rat | Clcn2 | NM_017137 | P35525 | |
ClC-3 | Human | CLCN3 | NM_173872 | P51790 |
Mouse | Clcn3 | NM_173874 | P51791 | |
Rat | Clcn3 | NM_053363 | P51792 | |
ClC-4 | Human | CLCN4 | NM_001830 | P51793 |
Mouse | Clcn4-2 | NM_011334 | Q61418 | |
Rat | Clcn4-2 | NM_022198 | Q56A19 | |
ClC-5 | Human | CLCN5 | NM_000084 | P51795 |
Mouse | Clcn5 | NM_016691 | Q9WVD4 | |
Rat | Clcn5 | NM_017106 | P51796 | |
ClC-6 | Human | CLCN6 | NM_001286 | Q5SNW2 |
Mouse | Clcn6 | NM_011929 | O35454 | |
Rat | Clcn6 | NM_001106479 | XP_227870 | |
ClC-7 | Human | CLCN7 | NM_001287 | P51798 |
Mouse | Clcn7 | NM_011930 | O70496 | |
Rat | Clcn7 | NM_031568 | P51799 | |
ClC-Ka | Human | CLCNKA | NM_001042704 | P51800 |
Mouse | Clcnka | NM_024412 | Q9WUB7 | |
Rat | Clcnka | NM_053327 | Q06393 | |
ClC-Kb | Human | CLCNKB | NM_000085 | P51801 |
Mouse | Clcnkb | NM_019701 | Q9WUB6 | |
Rat | Clcnkb | NM_173103 | Q1W583 | |
CaCC | Human | CLCA1 | NM_001285 | A8K7I4 |
Mouse | Clca1 | NM_009899 | NP_034029 | |
CaCC2 | Human | CLCA4 | NM_012128 | Q14CN2 |
Mouse | Clca4 | NM_139148 | NP_631887 | |
CFTR | Human | CFTR | NM_000492 | P13569 |
Mouse | Cftr | NM_021050 | P26361 | |
Rat | Cftr | NM_031506 | P34158 | |
CLIC1 | Human | CLIC1 | NM_001288 | O00299 |
Mouse | Clic1 | NM_033444 | Q9Z1Q5 | |
Rat | Clic1 | NM_001002807 | Q6MG61 | |
CLIC2 | Human | CLIC2 | NM_001289 | O15247 |
Rat | Clic2 | NM_001009651 | Q5M883 | |
CLIC3 | Human | CLIC3 | NM_004669 | O95833 |
Mouse | Clic3 | NM_027085 | Q9D7P7 | |
Rat | Clic3 | NM_001013080 | NP_001013098 | |
CLIC4 | Human | CLIC4 | NM_013943 | Q9Y696 |
Mouse | Clic4 | NM_013885 | Q9QYB1 | |
Rat | Clic4 | NM_031818 | Q9Z0W7 | |
CLIC5 | Human | CLIC5 | NM_016929 | Q9NZA1 |
Mouse | Clic5 | NM_172621 | Q8BXK9 | |
Rat | Clic5 | NM_053603 | Q9EPT8 | |
CLIC6 | Human | CLIC6 | NM_053277 | Q96NY7 |
Mouse | Clic6 | NM_172469 | Q8BHB9 | |
Rat | Clic6 | NM_176078 | Q811Q2 | |
CLNS1A | Human | CLNS1A | NM_001293 | P54105 |
Mouse | Clns1a | NM_023671 | Q61189 | |
Rat | Clns1a | NM_031719 | Q04753 |