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Biological Activity for Telenzepine dihydrochloride
Telenzepine dihydrochloride is a selective high affinity muscarinic M1 receptor antagonist (Ki = 0.94 nM). Inhibits gastric acid secretion.
Technical Data for Telenzepine dihydrochloride
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Telenzepine dihydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Telenzepine dihydrochloride
The following data is based on the product molecular weight 443.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.26 mL||11.28 mL||22.55 mL|
|5 mM||0.45 mL||2.26 mL||4.51 mL|
|10 mM||0.23 mL||1.13 mL||2.26 mL|
|50 mM||0.05 mL||0.23 mL||0.45 mL|
Product Datasheets for Telenzepine dihydrochloride
References for Telenzepine dihydrochloride
References are publications that support the biological activity of the product.
Christofi et al (1991) Neuropharmacology of the muscarinic antagonist telenzepine in myenteric ganglia of the guinea-pig small intestine. Eur.J.Pharmacol. 195 333 PMID: 1868879
Eltze et al (1985) Pharmacological evidence for selective inhibition of gastric acid secretion by telenzepine, a new antimuscarinic drug. Eur.J.Pharmacol. 112 211 PMID: 4029260
Galvan et al (1989) Interaction of telenzepine with muscarinic receptors in mammalian sympathetic ganglia. Eur.J.Pharmacol. 167 1 PMID: 2776837
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Keywords: Telenzepine dihydrochloride, Telenzepine dihydrochloride supplier, Potent, selective, M1, antagonists, Muscarinic, Receptors, Acetylcholine, ACh, 1122, Tocris Bioscience
1 Citation for Telenzepine dihydrochloride
Citations are publications that use Tocris products. Selected citations for Telenzepine dihydrochloride include:
Pediani et al (2016) Dynamic regulation of quaternary organization of the M1 muscarinic receptor by subtype-selective antagonist drugs. J.Biol.Chem. 291 13132 PMID: 27080256
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.