Telenzepine dihydrochloride

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Cat.No. 1122 - Telenzepine dihydrochloride | C19H22N4O2S.2HCl | CAS No. 147416-96-4
Description: Potent, selective M1 antagonist
Chemical Name: 4,9-Dihydro-3-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one dihydrochloride
Datasheet
Citations (1)

Biological Activity

Selective high affinity muscarinic M1 receptor antagonist (Ki = 0.94 nM). Inhibits gastric acid secretion.

Technical Data

M. Wt 443.39
Formula C19H22N4O2S.2HCl
Storage Store at RT
CAS Number 147416-96-4
PubChem ID 6321351
InChI Key SQKRUBZPTNJQEM-FQPARAGTSA-N
Smiles Cl.Cl.CN1CCN(CC(=O)N2C3=C(C)SC=C3C(=O)NC3=C2C=CC=C3)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 443.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.28 mL 22.55 mL
5 mM 0.45 mL 2.26 mL 4.51 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Christofi et al (1991) Neuropharmacology of the muscarinic antagonist telenzepine in myenteric ganglia of the guinea-pig small intestine. Eur.J.Pharmacol. 195 333 PMID: 1868879

Eltze et al (1985) Pharmacological evidence for selective inhibition of gastric acid secretion by telenzepine, a new antimuscarinic drug. Eur.J.Pharmacol. 112 211 PMID: 4029260

Galvan et al (1989) Interaction of telenzepine with muscarinic receptors in mammalian sympathetic ganglia. Eur.J.Pharmacol. 167 1 PMID: 2776837


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Keywords: Potent selective M1 antagonists Muscarinic Receptors Acetylcholine ACh M1 Receptors

1 Citation for Telenzepine dihydrochloride

Citations are publications that use Tocris products. Selected citations for Telenzepine dihydrochloride include:

Pediani et al (2016) Dynamic regulation of quaternary organization of the M1 muscarinic receptor by subtype-selective antagonist drugs. J.Biol.Chem. 291 13132 PMID: 27080256


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