Telenzepine dihydrochloride

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Description: Potent, selective M1 antagonist
Chemical Name: 4,9-Dihydro-3-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)

Biological Activity for Telenzepine dihydrochloride

Telenzepine dihydrochloride is a selective high affinity muscarinic M1 receptor antagonist (Ki = 0.94 nM). Inhibits gastric acid secretion.

Technical Data for Telenzepine dihydrochloride

M. Wt 443.39
Formula C19H22N4O2S.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 147416-96-4
PubChem ID 6419995
InChI Key JTQJFSQQHGPLOX-UHFFFAOYSA-N
Smiles Cl.Cl.CN1CCN(CC(=O)N2C3=C(C)SC=C3C(=O)NC3=C2C=CC=C3)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Telenzepine dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 44.34 100

Preparing Stock Solutions for Telenzepine dihydrochloride

The following data is based on the product molecular weight 443.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.28 mL 22.55 mL
5 mM 0.45 mL 2.26 mL 4.51 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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Product Datasheets for Telenzepine dihydrochloride

Certificate of Analysis / Product Datasheet
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References for Telenzepine dihydrochloride

References are publications that support the biological activity of the product.

Christofi et al (1991) Neuropharmacology of the muscarinic antagonist telenzepine in myenteric ganglia of the guinea-pig small intestine. Eur.J.Pharmacol. 195 333 PMID: 1868879

Eltze et al (1985) Pharmacological evidence for selective inhibition of gastric acid secretion by telenzepine, a new antimuscarinic drug. Eur.J.Pharmacol. 112 211 PMID: 4029260

Galvan et al (1989) Interaction of telenzepine with muscarinic receptors in mammalian sympathetic ganglia. Eur.J.Pharmacol. 167 1 PMID: 2776837


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Keywords: Telenzepine dihydrochloride, Telenzepine dihydrochloride supplier, Potent, selective, M1, antagonists, Muscarinic, Receptors, Acetylcholine, ACh, 1122, Tocris Bioscience

1 Citation for Telenzepine dihydrochloride

Citations are publications that use Tocris products. Selected citations for Telenzepine dihydrochloride include:

Pediani et al (2016) Dynamic regulation of quaternary organization of the M1 muscarinic receptor by subtype-selective antagonist drugs. J.Biol.Chem. 291 13132 PMID: 27080256


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Learning & Memory Poster

Learning & Memory Poster

Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.