Cevimeline hydrochloride

Pricing Availability   Qty
Description: Selective M1 agonist
Alternative Names: AF 102B,SNI 2011
Chemical Name: cis-2-Methylspiro[1,3-oxathiolane-5,3'-quinuclidine] hydrochloride
Datasheet
Citations (1)
Reviews
Literature (1)

Biological Activity for Cevimeline hydrochloride

Cevimeline hydrochloride is a selective M1 receptor agonist. Induces atropine-sensitive contractions of isolated guinea pig ilea and trachea preparations (EC50 values are 3.5 and 3 μM respectively). Reverses AF64A-induced cognitive impairments in vivo.

Technical Data for Cevimeline hydrochloride

M. Wt 235.77
Formula C10H17NOS.HCl
Storage Store at -20°C
CAS Number 107220-28-0
PubChem ID 76965955
InChI Key SKFLGMLYGHWKJG-RXUMEZLZSA-N
Smiles C[C@@H](SC3)O[C@@]13CN2CCC1CC2.C[C@H](SC6)O[C@]46CN5CCC4CC5.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Cevimeline hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 17.68 75
DMSO 11.79 50

Preparing Stock Solutions for Cevimeline hydrochloride

The following data is based on the product molecular weight 235.77. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 5.66 mL 28.28 mL 56.55 mL
3.75 mM 1.13 mL 5.66 mL 11.31 mL
7.5 mM 0.57 mL 2.83 mL 5.66 mL
37.5 mM 0.11 mL 0.57 mL 1.13 mL

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Product Datasheets for Cevimeline hydrochloride

Certificate of Analysis / Product Datasheet
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References for Cevimeline hydrochloride

References are publications that support the biological activity of the product.

Wanibuchi et al (1990) Pharmacological studies on novel muscarinic agonists, 1-oxa-8-azaspiro[4.5]decane derivatives, YM796 and YM954. Eur.J.Pharmacol. 187 479 PMID: 1963596

Fisher et al (1991) (+/-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease. J.Pharmacol.Exp.Ther. 257 392 PMID: 2019998

Hargreaves et al (1992) L-689,660, a novel cholinomimetic with functional selectivity for M1 and M3 muscarinic receptors. Br.J.Pharmacol. 107 494 PMID: 1422595


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Keywords: Cevimeline hydrochloride, Cevimeline hydrochloride supplier, AF102B, SNI2011, selective, M1, muscarinic, cholinergic, receptors, acetylcholine, Ach, agonists, AF, 102B, SNI, 2011, Receptors, 3689, Tocris Bioscience

1 Citation for Cevimeline hydrochloride

Citations are publications that use Tocris products. Selected citations for Cevimeline hydrochloride include:

Pasko et al (2020) Muscarinic M1 Receptors Modulate Working Memory Performance and Activity via KCNQ Potassium Channels in the Primate Prefrontal Cortex. Neuron 106 649-661.e4 PMID: 32197063


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Literature in this Area

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