Cevimeline hydrochloride

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Cat.No. 3689 - Cevimeline hydrochloride | C10H17NOS.HCl | CAS No. 107220-28-0
Description: Selective M1 agonist
Alternative Names: AF 102B, SNI 2011
Chemical Name: cis-2-Methylspiro[1,3-oxathiolane-5,3'-quinuclidine] hydrochloride

Biological Activity

Selective M1 receptor agonist. Induces atropine-sensitive contractions of isolated guinea pig ilea and trachea preparations (EC50 values are 3.5 and 3 μM respectively). Reverses AF64A-induced cognitive impairments in vivo.

Technical Data

M. Wt 235.77
Formula C10H17NOS.HCl
Storage Store at -20°C
CAS Number 107220-28-0
PubChem ID 76965955
Smiles C[C@@H](SC3)O[C@@]13CN2CCC1CC2.C[C@H](SC6)O[C@]46CN5CCC4CC5.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 17.68 75
DMSO 11.79 50

Preparing Stock Solutions

The following data is based on the product molecular weight 235.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 5.66 mL 28.28 mL 56.55 mL
3.75 mM 1.13 mL 5.66 mL 11.31 mL
7.5 mM 0.57 mL 2.83 mL 5.66 mL
37.5 mM 0.11 mL 0.57 mL 1.13 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Wanibuchi et al (1990) Pharmacological studies on novel muscarinic agonists, 1-oxa-8-azaspiro[4.5]decane derivatives, YM796 and YM954. Eur.J.Pharmacol. 187 479 PMID: 1963596

Fisher et al (1991) (+/-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease. J.Pharmacol.Exp.Ther. 257 392 PMID: 2019998

Hargreaves et al (1992) L-689,660, a novel cholinomimetic with functional selectivity for M1 and M3 muscarinic receptors. Br.J.Pharmacol. 107 494 PMID: 1422595

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Keywords: Cevimeline hydrochloride, Cevimeline hydrochloride supplier, AF102B, SNI2011, selective, M1, muscarinic, cholinergic, receptors, acetylcholine, Ach, agonists, AF, 102B, SNI, 2011, Receptors, 3689, Tocris Bioscience

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