Cevimeline hydrochloride

Pricing Availability   Qty
Description: Selective M1 agonist
Alternative Names: AF 102B,SNI 2011
Chemical Name: cis-2-Methylspiro[1,3-oxathiolane-5,3'-quinuclidine] hydrochloride
Citations (1)
Literature (1)

Biological Activity for Cevimeline hydrochloride

Cevimeline hydrochloride is a selective M1 receptor agonist. Induces atropine-sensitive contractions of isolated guinea pig ilea and trachea preparations (EC50 values are 3.5 and 3 μM respectively). Reverses AF64A-induced cognitive impairments in vivo.

Technical Data for Cevimeline hydrochloride

M. Wt 235.77
Formula C10H17NOS.HCl
Storage Store at -20°C
CAS Number 107220-28-0
PubChem ID 76965955
Smiles C[C@@H](SC3)O[C@@]13CN2CCC1CC2.C[C@H](SC6)O[C@]46CN5CCC4CC5.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Cevimeline hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 17.68 75
DMSO 11.79 50

Preparing Stock Solutions for Cevimeline hydrochloride

The following data is based on the product molecular weight 235.77. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 5.66 mL 28.28 mL 56.55 mL
3.75 mM 1.13 mL 5.66 mL 11.31 mL
7.5 mM 0.57 mL 2.83 mL 5.66 mL
37.5 mM 0.11 mL 0.57 mL 1.13 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Cevimeline hydrochloride

Certificate of Analysis / Product Datasheet
Select another batch:

References for Cevimeline hydrochloride

References are publications that support the biological activity of the product.

Wanibuchi et al (1990) Pharmacological studies on novel muscarinic agonists, 1-oxa-8-azaspiro[4.5]decane derivatives, YM796 and YM954. Eur.J.Pharmacol. 187 479 PMID: 1963596

Fisher et al (1991) (+/-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease. J.Pharmacol.Exp.Ther. 257 392 PMID: 2019998

Hargreaves et al (1992) L-689,660, a novel cholinomimetic with functional selectivity for M1 and M3 muscarinic receptors. Br.J.Pharmacol. 107 494 PMID: 1422595

If you know of a relevant reference for Cevimeline hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all M1 Receptor Agonists

Keywords: Cevimeline hydrochloride, Cevimeline hydrochloride supplier, AF102B, SNI2011, selective, M1, muscarinic, cholinergic, receptors, acetylcholine, Ach, agonists, AF, 102B, SNI, 2011, Receptors, 3689, Tocris Bioscience

1 Citation for Cevimeline hydrochloride

Citations are publications that use Tocris products. Selected citations for Cevimeline hydrochloride include:

Pasko et al (2020) Muscarinic M1 Receptors Modulate Working Memory Performance and Activity via KCNQ Potassium Channels in the Primate Prefrontal Cortex. Neuron 106 649-661.e4 PMID: 32197063

Do you know of a great paper that uses Cevimeline hydrochloride from Tocris? Please let us know.

Reviews for Cevimeline hydrochloride

There are currently no reviews for this product. Be the first to review Cevimeline hydrochloride and earn rewards!

Have you used Cevimeline hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.