Voltage-gated Calcium Channels (CaV)

Voltage-gated calcium channels (CaV) are present in the membrane of most excitable cells and mediate calcium influx in response to depolarization. They regulate intracellular processes such as contraction, secretion, neurotransmission and gene expression.

Products
Background
Literature
Gene Data

Activators

Cat No Product Name / Activity
1544 (±)-Bay K 8644
Ca2+ channel activator (L-type)
1546 (S)-(-)-Bay K 8644
Ca2+-channel activator (L-type)
1403 FPL 64176
Potent activator of Ca2+ channels (L-type)
2851 Nefiracetam
Cognitive enhancer; activates L/N-type Ca2+ channels

Blockers

Cat No Product Name / Activity
2799 ω-Agatoxin IVA
Ca2+ channel blocker (P-type)
2802 ω-Agatoxin TK
Ca2+ channel blocker (P/Q-type)
2571 Amlodipine besylate
Ca2+ channel blocker (L-type)
1545 (R)-(+)-Bay K 8644
Ca2+-channel blocker (L-type)
3934 Benidipine hydrochloride
Calcium channel blocker
4117 Bepridil hydrochloride
Non-selective calcium channel blocker
2629 Cilnidipine
Ca2+ channel blocker (dual L/N-type)
6170 Cinacalcet hydrochloride
L-type calcium channel blocker; also CaSR allosteric agonist and CYP2D2 inhibitor
1085 ω-Conotoxin GVIA
Ca2+ channel blocker (N-type)
1084 ω-Conotoxin MVIIC
Ca2+ channel blocker (N, P and Q-type)
0685 Diltiazem hydrochloride
Ca2+ channel blocker (L-type)
3733 Efonidipine hydrochloride monoethanolate
Ca2+ channel blocker (L- and T-type)
2960 Felodipine
Ca2+ channel blocker (L-type)
0522 Flunarizine dihydrochloride
Dual Na+/Ca2+ channel (T-type) blocker
5235 Huwentoxin XVI
Potent and reversible N-type Ca2+ channel blocker
2004 Isradipine
Ca2+ channel blocker (L-type)
3086 L-651,582
Ca2+ channel blocker
2959 Lercanidipine hydrochloride
Ca2+ channel blocker (L-type)
0840 Loperamide hydrochloride
Ca2+ channel blocker (HVA) (L/N-type)
2198 Mibefradil dihydrochloride
Ca2+ channel blocker (T-type)
4507 ML 218 hydrochloride
Ca2+ channel blocker (T-type)
1075 Nifedipine
Ca2+ channel blocker (L-type)
1124 (R)-(-)-Niguldipine hydrochloride
Ca2+ channel blocker (L-type). Less active enantiomer of Cat. No. 1123
1123 (S)-(+)-Niguldipine hydrochloride
Ca2+ channel blocker (L-type)
5711 Nilvadipine
Ca2+ channel blocker (L-type); also Syk kinase inhibitor
0600 Nimodipine
Ca2+ channel blocker (L-type)
0601 Nitrendipine
Ca2+ channel blocker (L-type)
2268 NNC 55-0396 dihydrochloride
Highly selective Ca2+ channel blocker (T-type)
3552 PD 173212
Potent N-type Ca2+ channel blocker
4665 ProTx I
CaV3.1 channel blocker; also inhibits NaV1.8 and KV2.1
1439 Ruthenium Red
Non-selective Ca2+ channel blocker (N- and P-type)
2945 SNX 482
Potent and selective CaV2.3 blocker (R-type)
1806 SR 33805 oxalate
Ca2+ channel blocker; binds allosterically to distinct site on L-type channels
0654 Verapamil hydrochloride
Ca2+ channel blocker (L-type)

Other

Cat No Product Name / Activity
4055 L-Ascorbic acid
Selective inhibitor of Cav3.2 channels
0806 Gabapentin
Selectively binds the α2δ subunit of CaV channels. Anticonvulsant
3775 Pregabalin
Anticonvulsant; selectively binds the α2δ subunit of voltage-sensitive calcium channels
5470 QAQ dichloride
Photoswitchable Nav, Kv and Cav channel blocker

Voltage-gated calcium channels (CaV) are present in the membrane of most excitable cells and mediate calcium influx in response to depolarization. They regulate intracellular processes such as contraction, secretion, neurotransmission and gene expression.

Voltage-gated calcium channels are formed from four or five distinct subunits; the α-subunit is the largest subunit and incorporates the voltage sensor, conduction pore and gating apparatus. Using pharmacological and electrophysiological techniques, at least 6 types of voltage-gated channels have been identified: L, N, P, Q, R and T, which are grouped into three families. Cav1.x are high-voltage-activated dihydropyridine-sensitive (L-type), Cav2.x are high-voltage-activated dihydropyridine-insensitive (N-, P- Q- and R-types) and Cav3.x are low-voltage-activated channels (T-type).

Literature for Voltage-gated Calcium Channels (CaV)

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Voltage-gated Calcium Channel Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Cav1.1 Human CACNA1S NM_000069 Q13698
Mouse Cacna1s NM_001081023 Q02789
Rat Cacna1s NM_053873 Q02485
Cav1.2 Human CACNA1C NM_000719 Q6PKM7
Mouse Cacna1c NM_009781 Q01815
Rat Cacna1c NM_012517 Q8VHT3
Cav1.3 Human CACNA1D NM_000720 Q01668
Mouse Cacna1d NM_001083616 Q99246
Rat Cacna1d NM_017298 Q91XN9
Cav1.4 Human CACNA1F NM_005183 O60840
Mouse Cacna1f NM_019582 Q9JIS7
Rat Cacna1f NM_053701 Q923Z7
Cav2.1 Human CACNA1A NM_000068 Q99793
Mouse Cacna1a NM_007578 P97445
Rat Cacna1a NM_012918 Q2YS39
Cav2.2 Human CACNA1B NM_000718 Q00975
Mouse Cacna1b NM_007579 O55017
Rat Cacna1b NM_147141 Q9R1B6
Cav2.3 Human CACNA1E NM_000721 Q15878
Mouse Cacna1e NM_009782 Q61290
Rat Cacna1e NM_019294 O35781
Cav3.1 Human CACNA1G NM_018896 Q9Y5T3
Mouse Cacna1g NM_009783 NP_033913
Rat Cacna1g NM_031601 Q9JL92
Cav3.2 Human CACNA1H NM_001005407 O95180
Mouse Cacna1h NM_021415 O88427
Rat Cacna1h NM_153814 Q9EQ60
Cav3.3 Human CACNA1I NM_001003406 Q9ULU9
Mouse Cacna1i NM_001044308 NP_001037773
Rat Cacna1i NM_020084 Q9Z0Y8