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ARN 11391 New
Biological Activity for ARN 11391
ARN 11391 is a potentiator of the IP3-gated calcium channel ITPR1 (Inositol 1,4,5-trisphosphate (IP3) receptor type 1). It amplifies intracellular calcium ion signaling by acting directly on ITPR1. ARN 11391 also potentiates calcium signaling in cells expressing mutant ITPR1 which is associated with SCA29, a form of spinocerebellar ataxia.
Technical Data for ARN 11391
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ARN 11391
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for ARN 11391
The following data is based on the product molecular weight 383.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.61 mL||13.04 mL||26.08 mL|
|5 mM||0.52 mL||2.61 mL||5.22 mL|
|10 mM||0.26 mL||1.3 mL||2.61 mL|
|50 mM||0.05 mL||0.26 mL||0.52 mL|
References for ARN 11391
References are publications that support the biological activity of the product.
Genovese et al (2022) Pharmacological potentiators of the calcium signaling cascade identified by high-throughput screening. PNAS Nexus 2 pgac288 PMID: 36712939
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Keywords: ARN 11391, ARN 11391 supplier, ARN11391, potentiator, calcium, ion, signaling, SCA29, spinocerebellar, ataxia, IP3, receptor, receptors, channel, channels, Receptors, 7909, Tocris Bioscience
Citations for ARN 11391
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