Pricing Availability   Qty
Description: Caged inositol triphosphate
Chemical Name: 6-O-[(4,5-Dimethoxy-2-nitrophenyl)methyl]-2,3-O-(1-methylethylidene)-D-myo-Inositol 1,4,5-tris[bis[(1-oxopropoxy)methyl]phosphate]
Purity: ≥98% (HPLC)
Citations (9)

Biological Activity for ci-IP3/PM

ci-IP3/PM is a caged inositol triphosphate. Cell permeable. UV photolysis (λ = 330 nm) in HeLa cells releases i-IP3, promoting Ca2+-release from internal stores.

F 127 (Cat. No. 6253) for the solubilization of ci-IP3/PM is also available.

Technical Data for ci-IP3/PM

M. Wt 1171.87
Formula C42H64NO31P3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1009832-82-9
PubChem ID 124221754
Smiles CC(O1)(C)O[C@H]([C@H]1[C@@H](OP(OCOC(CC)=O)(OCOC(CC)=O)=O)[C@@H]2OP(OCOC(CC)=O)(OCOC(CC)=O)=O)[C@@H](OP(OCOC(CC)=O)(OCOC(CC)=O)=O)[C@@H]2OCC3=CC(OC)=C(OC)C=C3[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ci-IP3/PM

Solubility Soluble in DMSO

Product Datasheets for ci-IP3/PM

Certificate of Analysis / Product Datasheet
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References for ci-IP3/PM

References are publications that support the biological activity of the product.

Dakin and Li et al (2007) Cell membrane permeable esters of D-myo-inositol 1,4,5-trisphosphate. Cell Calcium 42 291 PMID: 17307252

Lock et al (2017) Comparison of Ca2+ puffs evoked by extracellular agonists and photoreleased IP3. Cell Calcium PMID: 28108028

Zhang et al (2004) Endothelin-1 and IP3 induced Ca2+ sparks in pulmonary arterial smooth muscle cells. J.Cardiovasc.Pharmacol. 44 S121 PMID: 15838259

If you know of a relevant reference for ci-IP3/PM, please let us know.

Keywords: ci-IP3/PM, ci-IP3/PM supplier, Caged, IP3, activated, intracellular, Ca2+, calcium, stores, photolysis, UV, inositol, triphosphate, Second, Messenger, Compounds, Receptors, 6210, Tocris Bioscience

9 Citations for ci-IP3/PM

Citations are publications that use Tocris products. Selected citations for ci-IP3/PM include:

Sundeep et al (2021) CREB regulates the expression of type 1 inositol 1,4,5-trisphosphate receptors. J Cell Sci 134 PMID: 34533188

David I et al (2021) Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling. Cell Rep 34 108760 PMID: 33657364

David I et al (2021) A protocol for detecting elemental calcium signals (Ca2+ puffs) in mammalian cells using total internal reflection fluorescence microscopy. STAR Protoc 2 100618 PMID: 34195673

David I et al (2021) The Mitochondrial Ca2+ uniporter is a central regulator of interorganellar Ca2+ transfer and NFAT activation. J Biol Chem 297 101174 PMID: 34499925

Do you know of a great paper that uses ci-IP3/PM from Tocris? Please let us know.

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