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Description: Caged inositol triphosphate
Chemical Name: 6-O-[(4,5-Dimethoxy-2-nitrophenyl)methyl]-2,3-O-(1-methylethylidene)-D-myo-Inositol 1,4,5-tris[bis[(1-oxopropoxy)methyl]phosphate]
Purity: ≥98% (HPLC)
Citations (9)

Biological Activity for ci-IP3/PM

ci-IP3/PM is a caged inositol triphosphate. Cell permeable. UV photolysis (λ = 330 nm) in HeLa cells releases i-IP3, promoting Ca2+-release from internal stores.

F 127 (Cat. No. 6253) for the solubilization of ci-IP3/PM is also available.

Technical Data for ci-IP3/PM

M. Wt 1171.87
Formula C42H64NO31P3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1009832-82-9
PubChem ID 124221754
Smiles CC(O1)(C)O[C@H]([C@H]1[C@@H](OP(OCOC(CC)=O)(OCOC(CC)=O)=O)[C@@H]2OP(OCOC(CC)=O)(OCOC(CC)=O)=O)[C@@H](OP(OCOC(CC)=O)(OCOC(CC)=O)=O)[C@@H]2OCC3=CC(OC)=C(OC)C=C3[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ci-IP3/PM

Solubility Soluble in DMSO

Product Datasheets for ci-IP3/PM

Certificate of Analysis / Product Datasheet
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References for ci-IP3/PM

References are publications that support the biological activity of the product.

Dakin and Li et al (2007) Cell membrane permeable esters of D-myo-inositol 1,4,5-trisphosphate. Cell Calcium 42 291 PMID: 17307252

Lock et al (2017) Comparison of Ca2+ puffs evoked by extracellular agonists and photoreleased IP3. Cell Calcium PMID: 28108028

Zhang et al (2004) Endothelin-1 and IP3 induced Ca2+ sparks in pulmonary arterial smooth muscle cells. J.Cardiovasc.Pharmacol. 44 S121 PMID: 15838259

If you know of a relevant reference for ci-IP3/PM, please let us know.

Keywords: ci-IP3/PM, ci-IP3/PM supplier, Caged, IP3, activated, intracellular, Ca2+, calcium, stores, photolysis, UV, inositol, triphosphate, Second, Messenger, Compounds, Receptors, 6210, Tocris Bioscience

9 Citations for ci-IP3/PM

Citations are publications that use Tocris products. Selected citations for ci-IP3/PM include:

Sundeep et al (2022) Functional determination of calcium-binding sites required for the activation of inositol 1,4,5-trisphosphate receptors. Proc Natl Acad Sci U S A 119 e2209267119 PMID: 36122240

Yu et al (2022) Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes. Nat Commun 13 4481 PMID: 35918320

Jonathan et al (2023) Disruption of Mitochondrial-associated ER membranes by HIV-1 tat protein contributes to premature brain aging. CNS Neurosci Ther 29 365-377 PMID: 36419337

Tiziano et al (2023) Pharmacological potentiators of the calcium signaling cascade identified by high-throughput screening. PNAS Nexus 2 pgac288 PMID: 36712939

Do you know of a great paper that uses ci-IP3/PM from Tocris? Please let us know.

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