Formyl Peptide Receptors

The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi-protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes. FPRs are involved in antibacterial host defence and inflammation.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
5488 BML 111
FPR2 (lipoxin A4 receptor) agonist
1921 N-Formyl-Met-Leu-Phe
Endogenous FPR1 agonist
2826 FPR A14
FPR agonist
3537 MMK 1
Potent and selective FPR2 agonist
5583 Quin C1
Potent and selective FPR2 agonist
4624 TC-FPR 43
Potent FPR2 agonist
1799 WKYMVM
Selective FPR2 and FPR3 receptor agonist
1800 WKYMVm
FPR1, FPR2 and FPR3 receptor agonist

Antagonists

Cat No Product Name / Activity
3730 Boc-MLF
FPR1 antagonist
4611 PBP 10
Selective FPR2 antagonist; cell permeable
2262 WRW4
Selective FPR2 antagonist

Ligands

Cat No Product Name / Activity
3231 Ac9-25
Annexin I N-terminal peptide; acts as a FPR1 ligand

The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi-protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes and found at lower expression levels on endothelial cells, neurons, astrocytes and hepatocytes.

Formyl peptide receptors are involved in antibacterial host defence and inflammation. Activation of FPRs mediates induction of neutrophil chemotaxis and stimulation of the degranulation of neutrophils. In addition, FPRs have a role in neutrophil transcriptional regulation and cytokine production, and induce neutrophil apoptosis in a ROS-dependent manner. Recently, FPRs have been implicated in the pathogenesis of amyloidosis, Alzheimer's disease, prion diseases and HIV. Ligand diversity is a prominent and unusual feature of FPR family receptors, suggesting that these receptors may have more complex functions than are currently appreciated. The human genes encoding FPR1, FPR2 and FPR3 are clustered on chromosome 19q13.3-13.4.

External sources of pharmacological information for Formyl Peptide Receptors :

    Literature for Formyl Peptide Receptors

    GPCR

    GPCR Product Listing

    A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

    • Rhodopsin-like Receptors
    • Secretin-like Receptors
    • Glutamate Receptors
    • Frizzled Receptors
    • GPCR Signaling

    Formyl Peptide Receptor Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    FPR Human FPR1 NM_002029 P21462
    Mouse Fpr1 NM_013521 P33766
    FPR2 Human FPR2 NM_001005738 P25090
    Mouse Fpr2 NM_008039 NP_032065
    FPR3 Human FPR3 NM_002030 P25089