Quin C1

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Cat.No. 5583 - Quin C1 | C26H27N3O4 | CAS No. 786706-21-6
Description: Potent and selective FPR2 agonist
Chemical Name: 4-Butoxy-N-[1,4-dihydro-2-(4-methoxyphenyl)-4-oxo-3(2H)-quinazolinyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent and selective FPR2 agonist (EC50 = 40 nM). Induces Ca2+ mobilization in FPR2 but not FPR1-transfected mast cells. Induces neutrophil chemotaxis and degranulation in vitro. Reduces neutrophil and lymphocyte counts in bronchoalveolar lavage fluid in a mouse lung injury model. Anti-inflammatory.

Technical Data

M. Wt 445.51
Formula C26H27N3O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 786706-21-6
PubChem ID 11751175
InChI Key XORVAHQXRDLSFT-UHFFFAOYSA-N
Smiles O=C1N(NC(C2=CC=C(OCCCC)C=C2)=O)C(C3=CC=C(OC)C=C3)NC4=CC=CC=C41

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.55 100

Preparing Stock Solutions

The following data is based on the product molecular weight 445.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.24 mL 11.22 mL 22.45 mL
5 mM 0.45 mL 2.24 mL 4.49 mL
10 mM 0.22 mL 1.12 mL 2.24 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Zhou et al (2007) Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1. Mol.Pharmacol. 72 976 PMID: 17652444

Corminboeuf et al (2014) FPR2/ALXR agonists and the resolution of inflammation. J.Med.Chem. 58 537 PMID: 25365541


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1 Citation for Quin C1

Citations are publications that use Tocris products. Selected citations for Quin C1 include:

Ma et al (2015) Agonist and antagonist effects of aripiprazole on D2-like receptors controlling rat brain dopamine synthesis depend on the dopaminergic tone. Int J Neuropsychopharmacol 18 PMID: 25522390


Do you know of a great paper that uses Quin C1 from Tocris? If so please let us know.

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Literature in this Area

GPCR

GPCR Product Listing

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Pathways for Quin C1

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