Potent formyl peptide receptor 2 (FPR2) agonist (EC50 = 44 nM). Inhibits fMLP- and IL-8-induced neutrophil migration. Suppresses inflammation in a mouse model of acute inflammation. Orally bioavailable.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 384.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.6 mL||12.99 mL||25.98 mL|
|5 mM||0.52 mL||2.6 mL||5.2 mL|
|10 mM||0.26 mL||1.3 mL||2.6 mL|
|50 mM||0.05 mL||0.26 mL||0.52 mL|
References are publications that support the products' biological activity.
Dufton et al (2010) Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation. J.Immunol. 184 2611 PMID: 20107188
Bürli et al (2006) Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents. Bioorg.Med.Chem.Lett. 16 3713 PMID: 16697190
Forsman et al (2011) Stable formyl peptide receptor agonists that activate the neutrophil NADPH-oxidase identified through screening of a compound library. Biochem.Pharmacol. 81 402 PMID: 21095183
If you know of a relevant reference for TC-FPR 43, please let us know.
View Related Products by Product Action
Keywords: TC-FPR 43, supplier, TC-FPR43, potent, FPR2, anti-inflammatory, GPR32, agonists, neutrophils, migration, inflammation, anti-inflammatory, Formyl, Peptide, Receptors, Formyl, Peptide, Receptors, Tocris Bioscience
Citations for TC-FPR 43
Citations are publications that use Tocris products.
Currently there are no citations for TC-FPR 43. Do you know of a great paper that uses TC-FPR 43 from Tocris? If so please let us know.
Reviews for TC-FPR 43
There are currently no reviews for this product. Be the first to review TC-FPR 43 and earn rewards!
Have you used TC-FPR 43?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.