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Description: Potent FPR2 agonist
Chemical Name: N-(4-Chlorophenyl)-N-[2,3-dihydro-1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-1H-pyrazol-4-yl]-urea
Purity: ≥98% (HPLC)

Biological Activity for TC-FPR 43

TC-FPR 43 is a potent formyl peptide receptor 2 (FPR2) agonist (EC50 = 44 nM). Inhibits fMLP- and IL-8-induced neutrophil migration. Suppresses inflammation in a mouse model of acute inflammation. Orally bioavailable.

Compound Libraries for TC-FPR 43

TC-FPR 43 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TC-FPR 43

M. Wt 384.86
Formula C20H21ClN4O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 903895-98-7
PubChem ID 24776341
Smiles CC(C)C1=C(NC(NC3=CC=C(Cl)C=C3)=O)C(N(C2=CC=CC=C2)N1C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC-FPR 43

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 38.49 100

Preparing Stock Solutions for TC-FPR 43

The following data is based on the product molecular weight 384.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.6 mL 12.99 mL 25.98 mL
5 mM 0.52 mL 2.6 mL 5.2 mL
10 mM 0.26 mL 1.3 mL 2.6 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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References for TC-FPR 43

References are publications that support the biological activity of the product.

Dufton et al (2010) Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation. J.Immunol. 184 2611 PMID: 20107188

Bürli et al (2006) Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents. Bioorg.Med.Chem.Lett. 16 3713 PMID: 16697190

Forsman et al (2011) Stable formyl peptide receptor agonists that activate the neutrophil NADPH-oxidase identified through screening of a compound library. Biochem.Pharmacol. 81 402 PMID: 21095183

If you know of a relevant reference for TC-FPR 43, please let us know.

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Citations for TC-FPR 43

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