WKYMVm

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Cat.No. 1800 - WKYMVm | Trp-Lys-Tyr-Met-Val-D-Met-NH2 | CAS No. 187986-17-0
Description: FPR1, FPR2 and FPR3 receptor agonist
Alternative Names: Leukocyte chemoattractant peptide
Datasheet
Citations (2)

Biological Activity

Selective agonist for the formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM) and FPR3 (EC50 = 3 nM), expressed on immune cells. Induces Ca2+ mobilization and superoxide production in, and chemotaxic migration of, monocytes and neutrophils. Also promotes monocyte survival through a PKC-, PI 3-kinase- and Akt-dependent pathway.

Technical Data

M. Wt 856.11
Formula C41H61N9O7S2
Sequence WKYMVM

(Modifications: Met-6 = D-Met & C-terminal amide)

Storage Desiccate at -20°C
CAS Number 187986-17-0
PubChem ID 457933
InChI Key FMBGOORJEKQQLG-JUZZZACGSA-N
Smiles [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 856.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.17 mL 5.84 mL 11.68 mL
5 mM 0.23 mL 1.17 mL 2.34 mL
10 mM 0.12 mL 0.58 mL 1.17 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bae et al (2002) The synthetic chemoattractant peptide, Trp-Lys-Tyr-Met-Val-D-Met, enhances monocyte survival via PKC-dependent Akt activation. J.Leukoc.Biol. 71 329 PMID: 11818455

Christophe et al (2001) The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/Lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J.Biol.Chem. 276 21585 PMID: 11285256

Le et al (1999) Utilization of two seven-transmembrane, G protein-coupled receptors, formyl peptide receptor-like 1 and fomyl peptide receptor, by the synthetic hexapeptide WKYMVm for human phagocyte activation. J.Immunol. 163 6777 PMID: 10586077


If you know of a relevant reference for WKYMVm, please let us know.

View Related Products by Target

Keywords: FPR1 FPR2 FPR3 receptor agonists FPRL Formyl like Peptide Receptors Leukocyte chemoattractant peptide Formyl Peptide Receptor Peptide

2 Citations for WKYMVm

Citations are publications that use Tocris products. Selected citations for WKYMVm include:

Thompson et al (2014) Identification of a Novel Recycling Sequence in the C-tail of FPR2/ALX Receptor: ASSOCIATION WITH CELL PROTECTION FROM APOPTOSIS. J Biol Chem 289 36166 PMID: 25326384

Khau et al (2011) Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2. Invest Ophthalmol Vis Sci 25 483 PMID: 20930115


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