Selective agonist for the formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM) and FPR3 (EC50 = 3 nM), expressed on immune cells. Induces Ca2+ mobilization and superoxide production in, and chemotaxic migration of, monocytes and neutrophils. Also promotes monocyte survival through a PKC-, PI 3-kinase- and Akt-dependent pathway.
(Modifications: Met-6 = D-Met & C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 856.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.17 mL||5.84 mL||11.68 mL|
|5 mM||0.23 mL||1.17 mL||2.34 mL|
|10 mM||0.12 mL||0.58 mL||1.17 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
References are publications that support the products' biological activity.
Bae et al (2002) The synthetic chemoattractant peptide, Trp-Lys-Tyr-Met-Val-D-Met, enhances monocyte survival via PKC-dependent Akt activation. J.Leukoc.Biol. 71 329 PMID: 11818455
Christophe et al (2001) The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/Lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J.Biol.Chem. 276 21585 PMID: 11285256
Le et al (1999) Utilization of two seven-transmembrane, G protein-coupled receptors, formyl peptide receptor-like 1 and fomyl peptide receptor, by the synthetic hexapeptide WKYMVm for human phagocyte activation. J.Immunol. 163 6777 PMID: 10586077
If you know of a relevant reference for WKYMVm, please let us know.
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Keywords: WKYMVm, supplier, FPR1, FPR2, FPR3, receptor, agonists, FPRL, Formyl, like, Peptide, Receptors, Leukocyte, chemoattractant, peptide, Formyl, Peptide, Receptors, Formyl, Peptide, Receptors, Tocris Bioscience
2 Citations for WKYMVm
Citations are publications that use Tocris products. Selected citations for WKYMVm include:
Thompson et al (2014) Identification of a Novel Recycling Sequence in the C-tail of FPR2/ALX Receptor: ASSOCIATION WITH CELL PROTECTION FROM APOPTOSIS. J Biol Chem 289 36166 PMID: 25326384
Khau et al (2011) Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2. Invest Ophthalmol Vis Sci 25 483 PMID: 20930115
Do you know of a great paper that uses WKYMVm from Tocris? If so please let us know.
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