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Description: FPR1, FPR2 and FPR3 receptor agonist
Alternative Names: Leukocyte chemoattractant peptide
Purity: ≥95% (HPLC)
Citations (3)

Biological Activity for WKYMVm

WKYMVm is a selective agonist for the formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM) and FPR3 (EC50 = 3 nM), expressed on immune cells. Induces Ca2+ mobilization and superoxide production in, and chemotaxic migration of, monocytes and neutrophils. Also promotes monocyte survival through a PKC-, PI 3-kinase- and Akt-dependent pathway.

Technical Data for WKYMVm

M. Wt 856.11
Formula C41H61N9O7S2
Sequence WKYMVM

(Modifications: Met-6 = D-Met & C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 187986-17-0
PubChem ID 457933
Smiles [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for WKYMVm

Solubility Soluble to 2 mg/ml in water

Product Datasheets for WKYMVm

Certificate of Analysis / Product Datasheet
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Keywords: WKYMVm, WKYMVm supplier, FPR1, FPR2, FPR3, receptor, agonists, FPRL, Formyl, like, Peptide, Receptors, Leukocyte, chemoattractant, peptide, 1800, Tocris Bioscience

3 Citations for WKYMVm

Citations are publications that use Tocris products. Selected citations for WKYMVm include:

Khau et al (2011) Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2. Invest Ophthalmol Vis Sci 25 483 PMID: 20930115

Kienle et al (2021) Neutrophils self-limit swarming to contain bacterial growth in vivo Science 372 1262 PMID: 34140358

Thompson et al (2014) Identification of a Novel Recycling Sequence in the C-tail of FPR2/ALX Receptor: ASSOCIATION WITH CELL PROTECTION FROM APOPTOSIS. J Biol Chem 289 36166 PMID: 25326384

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