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Biological Activity for Boc-MLF
Boc-MLF is an antagonist of formyl peptide receptor 1 (FPR1). Reduces superoxide production induced by fMLF with an EC50 of 0.63 μM. Almost completely blocks fMLF-stimulated primary granule exocytosis.
Technical Data for Boc-MLF
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Boc-MLF
|Solubility||Soluble to 2 mg/ml in DMSO|
References for Boc-MLF
References are publications that support the biological activity of the product.
Boxio et al (2005) The immunostimulatory peptide WKYMVm-NH2 activates bone marrow mouse neutrophils via multiple signal transduction pathways. Scand.J.Immunol. 62 140 PMID: 16101820
Stenfeldt et al (2007) Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor. Inflammation 30 224 PMID: 17687636
Karlsson et al (2005) Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors. J.Leuko.Biol. 78 762
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Keywords: Boc-MLF, Boc-MLF supplier, formyl, peptide, receptor, 1, fMLF, FPR1, antagonists, Formyl, Peptide, Receptors, 3730, Tocris Bioscience
2 Citations for Boc-MLF
Citations are publications that use Tocris products. Selected citations for Boc-MLF include:
Cussell et al (2019) The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA. PLoS One 14 e0217815 PMID: 31170199
Sedlmayer et al (2018) Designer cells programming quorum-sensing interference with microbes. Nat Commun 9 1822 PMID: 29739943
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