Pricing Availability   Qty
Description: FPR1 antagonist
Purity: ≥95% (HPLC)
Citations (2)

Biological Activity for Boc-MLF

Boc-MLF is an antagonist of formyl peptide receptor 1 (FPR1). Reduces superoxide production induced by fMLF with an EC50 of 0.63 μM. Almost completely blocks fMLF-stimulated primary granule exocytosis.

Technical Data for Boc-MLF

M. Wt 509.66
Formula C25H39N3O6S
Sequence Boc-MLF
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 67247-12-5
PubChem ID 14655143
Smiles O=C([C@@H](NC([C@@H](NC(OC(C)(C)C)=O)CCSC)=O)CC(C)C)N[C@H]([C@@](O)=O)CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Boc-MLF

Solubility Soluble to 2 mg/ml in DMSO

Product Datasheets for Boc-MLF

Certificate of Analysis / Product Datasheet
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References for Boc-MLF

References are publications that support the biological activity of the product.

Boxio et al (2005) The immunostimulatory peptide WKYMVm-NH2 activates bone marrow mouse neutrophils via multiple signal transduction pathways. Scand.J.Immunol. 62 140 PMID: 16101820

Stenfeldt et al (2007) Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor. Inflammation 30 224 PMID: 17687636

Karlsson et al (2005) Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors. J.Leuko.Biol. 78 762

If you know of a relevant reference for Boc-MLF, please let us know.

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Keywords: Boc-MLF, Boc-MLF supplier, formyl, peptide, receptor, 1, fMLF, FPR1, antagonists, Formyl, Peptide, Receptors, 3730, Tocris Bioscience

2 Citations for Boc-MLF

Citations are publications that use Tocris products. Selected citations for Boc-MLF include:

Sedlmayer et al (2018) Designer cells programming quorum-sensing interference with microbes. Nat Commun 9 1822 PMID: 29739943

Cussell et al (2019) The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA. PLoS One 14 e0217815 PMID: 31170199

Do you know of a great paper that uses Boc-MLF from Tocris? Please let us know.

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