Boc-MLF

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Cat.No. 3730 - Boc-MLF | Boc-Met-Leu-Phe | CAS No. 67247-12-5
Description: FPR1 antagonist
Datasheet
Citations
Reviews
Literature

Biological Activity

Antagonist of formyl peptide receptor 1 (FPR1). Reduces superoxide production induced by fMLF with an EC50 of 0.63 μM. Almost completely blocks fMLF-stimulated primary granule exocytosis.

Technical Data

M. Wt 509.66
Formula C25H39N3O6S
Sequence Boc-MLF
Storage Store at -20°C
CAS Number 67247-12-5
PubChem ID 14655143
InChI Key GYBXWOPENJVQKE-UFYCRDLUSA-N
Smiles O=C([C@@H](NC([C@@H](NC(OC(C)(C)C)=O)CCSC)=O)CC(C)C)N[C@H]([C@@](O)=O)CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 2 mg/ml in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 509.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.96 mL 9.81 mL 19.62 mL
5 mM 0.39 mL 1.96 mL 3.92 mL
10 mM 0.2 mL 0.98 mL 1.96 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Boxio et al (2005) The immunostimulatory peptide WKYMVm-NH2 activates bone marrow mouse neutrophils via multiple signal transduction pathways. Scand.J.Immunol. 62 140 PMID: 16101820

Stenfeldt et al (2007) Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor. Inflammation 30 224 PMID: 17687636

Karlsson et al (2005) Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors. J.Leuko.Biol. 78 762


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Keywords: Boc-MLF, Boc-MLF supplier, formyl, peptide, receptor, 1, fMLF, FPR1, antagonists, Formyl, Peptide, Receptors, 3730, Tocris Bioscience

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Literature in this Area

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