N-Formyl-Met-Leu-Phe

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Cat.No. 1921 - N-Formyl-Met-Leu-Phe | N-Formyl-Met-Leu-Phe | CAS No. 59880-97-6
Description: Endogenous FPR1 agonist
Alternative Names: fMLP
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Endogenous chemotactic peptide and agonist for the formyl peptide receptor 1 (FPR1) (Ki = 38 nM). Stimulates aggregation of leukocytes.

Technical Data

M. Wt 437.55
Formula C21H31N3O5S
Sequence MLF

(Modifications: Met-1 = N-formyl-Met)

Storage Desiccate at -20°C
CAS Number 59880-97-6
PubChem ID 443295
InChI Key PRQROPMIIGLWRP-BZSNNMDCSA-N
Smiles CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 4.38 mg/ml in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 437.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.29 mL 11.43 mL 22.85 mL
5 mM 0.46 mL 2.29 mL 4.57 mL
10 mM 0.23 mL 1.14 mL 2.29 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Kreutzer et al (1978) Quantitative comparisons of various biological responses of neutrophils to different active and inactive chemotactic factors. Immunopharmacology 1 39 PMID: 45788

Mills et al (2000) Characterization of the binding site on the formyl peptide receptor using three receptor mutants and analogs of Met-Leu-Phe and Met-Met-Trp-Leu-Leu. J.Biol.Chem. 275 39012 PMID: 10960471

Spilberg et al (1984) Receptor blockade as a mechanism of deactivation of human neutrophils by pepstatin and formyl-Met-Leu-Phe. Inflammation 8 73 PMID: 6325345


If you know of a relevant reference for N-Formyl-Met-Leu-Phe, please let us know.

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View all Formyl Peptide Receptor Agonists

Keywords: N-Formyl-Met-Leu-Phe, N-Formyl-Met-Leu-Phe supplier, Endogenous, FPR1, agonists, FPRL, Formyl, Peptide, Receptors, fMLP, fMLF, 1921, Tocris Bioscience

2 Citations for N-Formyl-Met-Leu-Phe

Citations are publications that use Tocris products. Selected citations for N-Formyl-Met-Leu-Phe include:

Ding et al (2017) DAMPs Synergize with Cytokines or Fibronectin Fragment on Inducing Chondrolysis but Lose Effect When Acting Alone. Mediators Inflamm 2017 2642549 PMID: 28804219

Tomilov et al (2010) Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice. J Biol Chem 285 1153 PMID: 19892704


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