BML 111

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Description: FPR2 (lipoxin A4 receptor) agonist
Chemical Name: (5S,6R)-Methyl 5,6,7-trihydroxyheptanoate

Biological Activity for BML 111

BML 111 is a FPR2 (lipoxin A4 receptor) agonist. Suppresses tumor-related angiogenesis and reduces tumor growth in hepatoma H22 cell bearing mice. Also protects against hemorrhagic shock-induced acute lung injury in rats. Lipoxin A4 analog.

Technical Data for BML 111

M. Wt 192.21
Formula C8H16O5
Storage Store at -20°C
CAS Number 78606-80-1
PubChem ID 10899465
Smiles OC[C@@H](O)[C@@H](O)CCCC(OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BML 111

Solvent Max Conc. mg/mL Max Conc. mM
water 19.22 100
DMSO 19.22 100

Preparing Stock Solutions for BML 111

The following data is based on the product molecular weight 192.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.2 mL 26.01 mL 52.03 mL
5 mM 1.04 mL 5.2 mL 10.41 mL
10 mM 0.52 mL 2.6 mL 5.2 mL
50 mM 0.1 mL 0.52 mL 1.04 mL

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References for BML 111

References are publications that support the biological activity of the product.

Chen et al (2010) Lipoxin A4 and its analogue suppress the tumor growth of transplanted H22 in mice: the role of antiangiogenesis. Mol.Cancer.Ther. 9 2164 PMID: 20682645

Gong et al (2012) BML-111, a lipoxin receptor agonist, protects haemorrhagic shock-induced acute lung injury in rats. Resuscitation. 83 907 PMID: 22245750

If you know of a relevant reference for BML 111, please let us know.

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Citations for BML 111

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