BML 111

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Cat.No. 5488 - BML 111 | C8H16O5 | CAS No. 78606-80-1
Description: FPR2 (lipoxin A4 receptor) agonist
Chemical Name: (5S,6R)-Methyl 5,6,7-trihydroxyheptanoate
Datasheet
Citations
Literature

Biological Activity

FPR2 (lipoxin A4 receptor) agonist. Suppresses tumor-related angiogenesis and reduces tumor growth in hepatoma H22 cell bearing mice. Also protects against hemorrhagic shock-induced acute lung injury in rats. Lipoxin A4 analog.

Technical Data

M. Wt 192.21
Formula C8H16O5
Storage Store at -20°C
CAS Number 78606-80-1
PubChem ID 10899465
InChI Key RNMFWAFZUNVQOR-NKWVEPMBSA-N
Smiles OC[C@@H](O)[C@@H](O)CCCC(OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.22 100
water 19.22 100

Preparing Stock Solutions

The following data is based on the product molecular weight 192.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.2 mL 26.01 mL 52.03 mL
5 mM 1.04 mL 5.2 mL 10.41 mL
10 mM 0.52 mL 2.6 mL 5.2 mL
50 mM 0.1 mL 0.52 mL 1.04 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Chen et al (2010) Lipoxin A4 and its analogue suppress the tumor growth of transplanted H22 in mice: the role of antiangiogenesis. Mol.Cancer.Ther. 9 2164 PMID: 20682645

Gong et al (2012) BML-111, a lipoxin receptor agonist, protects haemorrhagic shock-induced acute lung injury in rats. Resuscitation. 83 907 PMID: 22245750


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