WRW4

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Cat.No. 2262 - WRW4 | Trp-Arg-Trp-Trp-Trp-Trp-NH2 | CAS No. 878557-55-2
Description: Selective FPR2 antagonist
Alternative Names: WRW4
Datasheet
Citations (5)

Biological Activity

Selective antagonist of formyl peptide receptor 2 (FPR2) signaling. Inhibits WKYMVm binding to FPR2 (IC50 = 0.23 μM) and inhibits intracellular calcium release induced by WKYMVm, MMK 1, amyloid β42, and F peptide. Also inhibits FPR2-mediated signaling in human neutrophils; blocks chemotactic migration and superoxide generation by amyloid β42 peptide.

Technical Data

M. Wt 1104.28
Formula C61H65N15O6
Sequence WRWWWW

(Modifications: Trp-6 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 878557-55-2
PubChem ID 49768327
InChI Key IRJDOVLLPORVJP-WOAIKHIASA-N
Smiles [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1104.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.91 mL 4.53 mL 9.06 mL
5 mM 0.18 mL 0.91 mL 1.81 mL
10 mM 0.09 mL 0.45 mL 0.91 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bae et al (2004) Identification of peptides that antagonize formyl peptide receptor-like 1-mediating signaling. J.Immunol. 173 607 PMID: 15210823


If you know of a relevant reference for WRW4, please let us know.

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Keywords: Selective FPR2 antagonists FPRL Formyl Peptide Receptors WRW4 Formyl Peptide Receptor Peptide

5 Citations for WRW4

Citations are publications that use Tocris products. Selected citations for WRW4 include:

Khau et al (2011) Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2. Korean J Physiol Pharmacol 25 483 PMID: 20930115

Hasan et al (2014) Scant Extracellular NAD Cleaving Activity of Human Neutrophils is Down-Regulated by fMLP via FPRL1. BMC Mol Biol 18 497 PMID: 25598664

Barnig et al (2013) Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma. Sci Transl Med 5 174ra26 PMID: 23447017

Leoni et al (2013) Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest 123 443 PMID: 23241962

Tristão et al (2013) 5-Lipoxygenase activity increases susceptibility to experimental Paracoccidioides brasiliensis infection. Infect Immun 81 1256 PMID: 23381993


Do you know of a great paper that uses WRW4 from Tocris? If so please let us know.

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