WRW4

Pricing Availability   Qty
Description: Selective FPR2 antagonist
Alternative Names: WRW4
Purity: ≥95% (HPLC)
Datasheet
Citations (9)
Reviews (1)
Literature (1)

Biological Activity for WRW4

WRW4 is a selective antagonist of formyl peptide receptor 2 (FPR2) signaling. Inhibits WKYMVm binding to FPR2 (IC50 = 0.23 μM) and inhibits intracellular calcium release induced by WKYMVm, MMK 1, amyloid β42, and F peptide. Also inhibits FPR2-mediated signaling in human neutrophils; blocks chemotactic migration and superoxide generation by amyloid β42 peptide.

Technical Data for WRW4

M. Wt 1104.28
Formula C61H65N15O6
Sequence WRWWWW

(Modification: Trp-6 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 878557-55-2
PubChem ID 49768327
InChI Key IRJDOVLLPORVJP-WOAIKHIASA-N
Smiles [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for WRW4

Solubility Soluble to 1 mg/ml in water

Product Datasheets for WRW4

Certificate of Analysis / Product Datasheet
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References for WRW4

References are publications that support the biological activity of the product.

Bae et al (2004) Identification of peptides that antagonize formyl peptide receptor-like 1-mediating signaling. J.Immunol. 173 607 PMID: 15210823


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View Related Products by Product Action

View all Formyl Peptide Receptor Antagonists

Keywords: WRW4, WRW4 supplier, Selective, FPR2, antagonists, FPRL, Formyl, Peptide, Receptors, WRW4, 2262, Tocris Bioscience

9 Citations for WRW4

Citations are publications that use Tocris products. Selected citations for WRW4 include:

Cussell et al (2019) The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA. PLoS One 14 e0217815 PMID: 31170199

Khau et al (2011) Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2. Korean J Physiol Pharmacol 25 483 PMID: 20930115

Rhys et al (2018) Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages. EBioMedicine 29 60 PMID: 29449195

Wenceslau et al (2015) Mitochondrial N-formyl peptides induce cardiovascular collapse and sepsis-like syndrome. Am J Physiol Heart Circ Physiol 308 H768 PMID: 25637548


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Reviews for WRW4

Average Rating: 3 (Based on 1 Review.)

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it's ok.
By Christopher Durrant on 01/09/2020
Assay Type: Ex Vivo
Species: Human

for formyl peptide receptor 2 (FPR2) signaling

Followed publication, it worked, great


Literature in this Area

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