WRW4

Pricing Availability   Qty
Cat.No. 2262 - WRW4 | Trp-Arg-Trp-Trp-Trp-Trp-NH2 | CAS No. 878557-55-2
Description: Selective FPR2 antagonist
Alternative Names: WRW4
Datasheet
Citations (8)
Reviews (1)
Literature (1)

Biological Activity for WRW4

WRW4 is a selective antagonist of formyl peptide receptor 2 (FPR2) signaling. Inhibits WKYMVm binding to FPR2 (IC50 = 0.23 μM) and inhibits intracellular calcium release induced by WKYMVm, MMK 1, amyloid β42, and F peptide. Also inhibits FPR2-mediated signaling in human neutrophils; blocks chemotactic migration and superoxide generation by amyloid β42 peptide.

Technical Data for WRW4

M. Wt 1104.28
Formula C61H65N15O6
Sequence WRWWWW

(Modifications: Trp-6 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 878557-55-2
PubChem ID 49768327
InChI Key IRJDOVLLPORVJP-WOAIKHIASA-N
Smiles [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for WRW4

Solubility Soluble to 1 mg/ml in water

Product Datasheets for WRW4

Certificate of Analysis / Product Datasheet
Select another batch:

References for WRW4

References are publications that support the biological activity of the product.

Bae et al (2004) Identification of peptides that antagonize formyl peptide receptor-like 1-mediating signaling. J.Immunol. 173 607 PMID: 15210823


If you know of a relevant reference for WRW4, please let us know.

View Related Products by Product Action

View all Formyl Peptide Receptor Antagonists

Keywords: WRW4, WRW4 supplier, Selective, FPR2, antagonists, FPRL, Formyl, Peptide, Receptors, WRW4, 2262, Tocris Bioscience

8 Citations for WRW4

Citations are publications that use Tocris products. Selected citations for WRW4 include:

Cussell et al (2019) The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA. PLoS One 14 e0217815 PMID: 31170199

Wenceslau et al (2015) Mitochondrial N-formyl peptides induce cardiovascular collapse and sepsis-like syndrome. Am J Physiol Heart Circ Physiol 308 H768 PMID: 25637548

Rhys et al (2018) Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages. EBioMedicine 29 60 PMID: 29449195

Hasan et al (2014) Scant Extracellular NAD Cleaving Activity of Human Neutrophils is Down-Regulated by fMLP via FPRL1. BMC Mol Biol 18 497 PMID: 25598664


Do you know of a great paper that uses WRW4 from Tocris? Please let us know.

Reviews for WRW4

Average Rating: 3 (Based on 1 Review.)

5 Star
0%
4 Star
0%
3 Star
100%
2 Star
0%
1 Star
0%

Have you used WRW4?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


it's ok.
By Christopher Durrant on 01/09/2020
Assay Type: Ex Vivo
Species: Human

for formyl peptide receptor 2 (FPR2) signaling

Followed publication, it worked, great


Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling