Pricing Availability   Qty
Description: Selective FPR2 antagonist
Alternative Names: WRW4
Purity: ≥95% (HPLC)
Citations (9)
Reviews (1)

Biological Activity for WRW4

WRW4 is a selective antagonist of formyl peptide receptor 2 (FPR2) signaling. Inhibits WKYMVm binding to FPR2 (IC50 = 0.23 μM) and inhibits intracellular calcium release induced by WKYMVm, MMK 1, amyloid β42, and F peptide. Also inhibits FPR2-mediated signaling in human neutrophils; blocks chemotactic migration and superoxide generation by amyloid β42 peptide.

Technical Data for WRW4

M. Wt 1104.28
Formula C61H65N15O6
Sequence WRWWWW

(Modification: Trp-6 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 878557-55-2
PubChem ID 49768327
Smiles [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for WRW4

Solubility Soluble to 1 mg/ml in water

Product Datasheets for WRW4

Certificate of Analysis / Product Datasheet
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References for WRW4

References are publications that support the biological activity of the product.

Bae et al (2004) Identification of peptides that antagonize formyl peptide receptor-like 1-mediating signaling. J.Immunol. 173 607 PMID: 15210823

If you know of a relevant reference for WRW4, please let us know.

View Related Products by Product Action

View all Formyl Peptide Receptor Antagonists

Keywords: WRW4, WRW4 supplier, Selective, FPR2, antagonists, FPRL, Formyl, Peptide, Receptors, WRW4, 2262, Tocris Bioscience

9 Citations for WRW4

Citations are publications that use Tocris products. Selected citations for WRW4 include:

Rhys et al (2018) Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages. EBioMedicine 29 60 PMID: 29449195

Khau et al (2011) Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2. Korean J Physiol Pharmacol 25 483 PMID: 20930115

Kienle et al (2021) Neutrophils self-limit swarming to contain bacterial growth in vivo. Science 372 1262 PMID: 34140358

Hasan et al (2014) Scant Extracellular NAD Cleaving Activity of Human Neutrophils is Down-Regulated by fMLP via FPRL1. BMC Mol Biol 18 497 PMID: 25598664

Do you know of a great paper that uses WRW4 from Tocris? Please let us know.

Reviews for WRW4

Average Rating: 3 (Based on 1 Review.)

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it's ok.
By Christopher Durrant on 01/09/2020
Assay Type: Ex Vivo
Species: Human

for formyl peptide receptor 2 (FPR2) signaling

Followed publication, it worked, great