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Biological Activity for WRW4
WRW4 is a selective antagonist of formyl peptide receptor 2 (FPR2) signaling. Inhibits WKYMVm binding to FPR2 (IC50 = 0.23 μM) and inhibits intracellular calcium release induced by WKYMVm, MMK 1, amyloid β42, and F peptide. Also inhibits FPR2-mediated signaling in human neutrophils; blocks chemotactic migration and superoxide generation by amyloid β42 peptide.
Technical Data for WRW4
(Modification: Trp-6 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for WRW4
|Solubility||Soluble to 1 mg/ml in water|
References for WRW4
References are publications that support the biological activity of the product.
Bae et al (2004) Identification of peptides that antagonize formyl peptide receptor-like 1-mediating signaling. J.Immunol. 173 607 PMID: 15210823
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Keywords: WRW4, WRW4 supplier, Selective, FPR2, antagonists, FPRL, Formyl, Peptide, Receptors, WRW4, 2262, Tocris Bioscience
9 Citations for WRW4
Citations are publications that use Tocris products. Selected citations for WRW4 include:
Kienle et al (2021) Neutrophils self-limit swarming to contain bacterial growth in vivo. Science 372 1262 PMID: 34140358
Cussell et al (2019) The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA. PLoS One 14 e0217815 PMID: 31170199
Wenceslau et al (2015) Mitochondrial N-formyl peptides induce cardiovascular collapse and sepsis-like syndrome. Am J Physiol Heart Circ Physiol 308 H768 PMID: 25637548
Barnig et al (2013) Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma. Sci Transl Med 5 174ra26 PMID: 23447017
Leoni et al (2013) Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest 123 443 PMID: 23241962
Tristão et al (2013) 5-Lipoxygenase activity increases susceptibility to experimental Paracoccidioides brasiliensis infection. Infect Immun 81 1256 PMID: 23381993
Hasan et al (2014) Scant Extracellular NAD Cleaving Activity of Human Neutrophils is Down-Regulated by fMLP via FPRL1. BMC Mol Biol 18 497 PMID: 25598664
Khau et al (2011) Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2. Korean J Physiol Pharmacol 25 483 PMID: 20930115
Rhys et al (2018) Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages. EBioMedicine 29 60 PMID: 29449195
Do you know of a great paper that uses WRW4 from Tocris? Please let us know.
Reviews for WRW4
Average Rating: 3 (Based on 1 Review.)
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for formyl peptide receptor 2 (FPR2) signaling
Followed publication, it worked, great
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.