Saxagliptin hydrochloride

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Cat.No. 6507 - Saxagliptin hydrochloride | C18H25N3O2.HCl | CAS No. 709031-78-7
Description: High affinity DPP-IV inhibitor; active in vivo
Alternative Names: BMS 477118
Chemical Name: (1S,3S,5S)-2-[(2S)-Amino(3-hydroxytricyclo[,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride
Purity: ≥98% (HPLC)
Reviews (1)
Literature (1)

Biological Activity

High affinity DPP-IV inhibitor (Ki = 0.6 nM). Inhibits plasma DPP-IV (87%). Elicits enhanced glucose clearance in Zuckerfa/fa rats.

Compound Libraries

Saxagliptin hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 351.87
Formula C18H25N3O2.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 709031-78-7
PubChem ID 56841574
Smiles N[C@@H](C12CC3CC(C2)CC(C3)(C1)O)C(N4[C@H]5C[C@H]5C[C@H]4C#N)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 35.19 100
DMSO 35.19 100

Preparing Stock Solutions

The following data is based on the product molecular weight 351.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.21 mL 28.42 mL
5 mM 0.57 mL 2.84 mL 5.68 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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References are publications that support the biological activity of the product.

Augeri et al (2005) Discovery and preclinical profile of saxagl. (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J.Med.Chem. 48 5025 PMID: 16033281

If you know of a relevant reference for Saxagliptin hydrochloride, please let us know.

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Citations for Saxagliptin hydrochloride

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Currently there are no citations for Saxagliptin hydrochloride. Do you know of a great paper that uses Saxagliptin hydrochloride from Tocris? Please let us know.

Reviews for Saxagliptin hydrochloride

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Saxagliptin impairs cardiac contractility.
By Christopher Trummer on 10/15/2018
Assay Type: Ex Vivo
Species: Other
Cell Line/Tissue: heart

Guinea pig hearts were isolated and mounted on a Langendorff's setup followed by perfusion with Krebs-Henseleit solution alone or containing saxagliptin (2 µM) for 30 min. The protocol of Langendorff perfusion of isolated guinea pig hearts is displayed in the upper panel. Saxagliptin significantly impaired left ventricular developed pressure compared to controls.

review image

Literature in this Area

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