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Biological Activity for Saxagliptin hydrochloride
Saxagliptin hydrochloride is a high affinity DPP-IV inhibitor (Ki = 0.6 nM). Inhibits plasma DPP-IV (87%). Elicits enhanced glucose clearance in Zuckerfa/fa rats.
Compound Libraries for Saxagliptin hydrochloride
Technical Data for Saxagliptin hydrochloride
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Saxagliptin hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Saxagliptin hydrochloride
The following data is based on the product molecular weight 351.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.84 mL||14.21 mL||28.42 mL|
|5 mM||0.57 mL||2.84 mL||5.68 mL|
|10 mM||0.28 mL||1.42 mL||2.84 mL|
|50 mM||0.06 mL||0.28 mL||0.57 mL|
Product Datasheets for Saxagliptin hydrochloride
References for Saxagliptin hydrochloride
References are publications that support the biological activity of the product.
Augeri et al (2005) Discovery and preclinical profile of saxagl. (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J.Med.Chem. 48 5025 PMID: 16033281
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Citations for Saxagliptin hydrochloride
Citations are publications that use Tocris products.
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Reviews for Saxagliptin hydrochloride
Average Rating: 5 (Based on 1 Review.)
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Guinea pig hearts were isolated and mounted on a Langendorff's setup followed by perfusion with Krebs-Henseleit solution alone or containing saxagliptin (2 µM) for 30 min. The protocol of Langendorff perfusion of isolated guinea pig hearts is displayed in the upper panel. Saxagliptin significantly impaired left ventricular developed pressure compared to controls.