GRP (human)

Pricing Availability   Qty
Description: Endogenous GRP receptor agonist
Alternative Names: Gastrin-releasing peptide (human)
Purity: ≥95% (HPLC)
Datasheet
Citations (6)
Reviews
Literature (1)

Biological Activity for GRP (human)

GRP (human) is a mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice in vivo. Also involved in mitogenesis, and GI tract and appetite regulation.

Technical Data for GRP (human)

M. Wt 2859.4
Formula C130H204N38O31S2
Sequence VPLPAGGGTVLTKMYPRGNHWAVGHLM

(Modifications: Met-27 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 93755-85-2
PubChem ID 16143985
InChI Key PUBCCFNQJQKCNC-XKNFJVFFSA-N
Smiles [H]N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GRP (human)

Solubility Soluble to 1 mg/ml in water

Product Datasheets for GRP (human)

Certificate of Analysis / Product Datasheet
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References for GRP (human)

References are publications that support the biological activity of the product.

Benya et al (1995) Expression and characterization of cloned human bombesin receptors. Mol.Pharmacol. 47 10 PMID: 7838118

Dudai (2003) Neurobiology: Fear thou not. Nature 421 325 PMID: 12540884

Shumyatsky et al (2002) Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. Cell 111 905 PMID: 12526815

Woodruff et al (1996) Bombesin receptors in the brain. Ann.N.Y.Acad.Sci. 780 223 PMID: 8602736


If you know of a relevant reference for GRP (human), please let us know.

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Keywords: GRP (human), GRP (human) supplier, Endogenous, GRP, receptor, agonists, GRP-Preferring, Receptors, BB2, Gastrin-Releasing, Peptide-Preferring, Bombesin, Gastrin-releasing, peptide, (human), 1789, Tocris Bioscience

6 Citations for GRP (human)

Citations are publications that use Tocris products. Selected citations for GRP (human) include:

Solorzano et al (2015) Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns. Sci Rep 35 648 PMID: 25589759

Blais et al (2016) Gastrin-releasing peptide receptor mediates the excitation of preoptic GABAergic neurons by bombesin Neuroscience Letters 633 262 PMID: 27693662

Gey et al (2016) Atf3 mutant mice show reduced axon regeneration and impaired regeneration-associated gene induction after peripheral nerve injury. Open Biol 6 PMID: 27581653

Shehan et al (2020) The neurokinin-1 receptor is expressed with gastrin-releasing peptide receptor in spinal interneurons and modulates itch. J Neurosci 40 8816 PMID: 33051347


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.