GRP (human)

Pricing Availability Delivery Time Qty
Cat.No. 1789 - GRP (human) | Val-Pro-Leu-Pro-Ala-Gly-Gly-Gly-Thr-Val-Leu-Thr-Lys-Met-Tyr-Pro-Arg-Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2 | CAS No. 93755-85-2
Description: Endogenous GRP receptor agonist
Alternative Names: Gastrin-releasing peptide (human)
Datasheet
Citations (4)
Literature

Biological Activity

Mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice in vivo. Also involved in mitogenesis, and GI tract and appetite regulation.

Technical Data

M. Wt 2859.4
Formula C130H204N38O31S2
Sequence VPLPAGGGTVLTKMYPRGNHWAVGHLM

(Modifications: Met-27 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 93755-85-2
PubChem ID 16143985
InChI Key PUBCCFNQJQKCNC-XKNFJVFFSA-N
Smiles [H]N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2859.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.35 mL 1.75 mL 3.5 mL
5 mM 0.07 mL 0.35 mL 0.7 mL
10 mM 0.03 mL 0.17 mL 0.35 mL
50 mM 0.01 mL 0.03 mL 0.07 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Benya et al (1995) Expression and characterization of cloned human bombesin receptors. Mol.Pharmacol. 47 10 PMID: 7838118

Dudai (2003) Neurobiology: Fear thou not. Nature 421 325 PMID: 12540884

Shumyatsky et al (2002) Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. Cell 111 905 PMID: 12526815

Woodruff et al (1996) Bombesin receptors in the brain. Ann.N.Y.Acad.Sci. 780 223 PMID: 8602736


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View all Bombesin Receptor Agonists

Keywords: GRP (human), supplier, Endogenous, GRP, receptor, agonists, GRP-Preferring, Receptors, BB2, Gastrin-Releasing, Peptide-Preferring, Bombesin, Gastrin-releasing, peptide, (human), Bombesin, Receptors, Bombesin, Receptors, Tocris Bioscience

4 Citations for GRP (human)

Citations are publications that use Tocris products. Selected citations for GRP (human) include:

Kim et al (2013) Enhanced autophagy blocks angiogenesis via degradation of gastrin-releasing peptide in neuroblastoma cells. J Neurosci 9 1579 PMID: 24108003

Blais et al (2016) Gastrin-releasing peptide receptor mediates the excitation of preoptic GABAergic neurons by bombesin Neuroscience Letters 633 262 PMID: 27693662

Solorzano et al (2015) Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns. Sci Rep 35 648 PMID: 25589759

Lee and Ko (2015) Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates. Int J Inflam 5 11676 PMID: 26119696


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