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DPPI 1c hydrochloride
Biological Activity for DPPI 1c hydrochloride
DPPI 1c hydrochloride is an inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50 = 104 nM) that displays selectivity over enzymes with DPP-like activity (IC50 > 30 μM). Increases plasma GLP-1 levels and improves glucose tolerance in diabetic mice following oral glucose challenge.
Compound Libraries for DPPI 1c hydrochloride
Technical Data for DPPI 1c hydrochloride
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for DPPI 1c hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for DPPI 1c hydrochloride
The following data is based on the product molecular weight 312.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.2 mL||15.98 mL||31.97 mL|
|5 mM||0.64 mL||3.2 mL||6.39 mL|
|10 mM||0.32 mL||1.6 mL||3.2 mL|
|50 mM||0.06 mL||0.32 mL||0.64 mL|
Product Datasheets for DPPI 1c hydrochloride
References for DPPI 1c hydrochloride
References are publications that support the biological activity of the product.
Wright et al (2006) cis-2-5-dicyanopyrrolidine inhibitors of dipeptidyl peptidase IV: synthesis and in vitro, in vivo, and X-ray crystallographic characterization. J.Med.Chem. 49 3068 PMID: 16722626
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Keywords: DPPI 1c hydrochloride, DPPI 1c hydrochloride supplier, Dipeptidyl, peptidase, IV, DPP-IV, inhibitors, inhibits, Peptidase, Proteinases, Proteases, DPPI1c, hydrochloride, 866396-34-1, DPP4, (DPP-IV), 2783, Tocris Bioscience
Citations for DPPI 1c hydrochloride
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