DPPI 1c hydrochloride

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Cat.No. 2783 - DPPI 1c hydrochloride | C14H20N4O2.HCl | CAS No. 866396-70-5
Description: Dipeptidyl peptidase IV (DPP-IV) inhibitor
Chemical Name: 1-[[[(1-Hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-cis-pyrrolidinedicarbonitrile hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50 = 104 nM) that displays selectivity over enzymes with DPP-like activity (IC50 > 30 μM). Increases plasma GLP-1 levels and improves glucose tolerance in diabetic mice following oral glucose challenge.

Technical Data

M. Wt 312.8
Formula C14H20N4O2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 866396-70-5
PubChem ID 11381415
InChI Key RHCWAHDCHQTNBR-IWKKHLOMSA-N
Smiles O=C(CNC2(CO)CCCC2)N1[C@@H](C#N)CC[C@H]1C#N.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.28 100
ethanol 7.82 25
water 15.64 50

Preparing Stock Solutions

The following data is based on the product molecular weight 312.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.2 mL 15.98 mL 31.97 mL
5 mM 0.64 mL 3.2 mL 6.39 mL
10 mM 0.32 mL 1.6 mL 3.2 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Wright et al (2006) cis-2-5-dicyanopyrrolidine inhibitors of dipeptidyl peptidase IV: synthesis and in vitro, in vivo, and X-ray crystallographic characterization. J.Med.Chem. 49 3068 PMID: 16722626


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