DPPI 1c hydrochloride

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Description: Dipeptidyl peptidase IV (DPP-IV) inhibitor
Chemical Name: 1-[[[(1-Hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-cis-pyrrolidinedicarbonitrile hydrochloride
Purity: ≥98% (HPLC)

Biological Activity for DPPI 1c hydrochloride

DPPI 1c hydrochloride is an inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50 = 104 nM) that displays selectivity over enzymes with DPP-like activity (IC50 > 30 μM). Increases plasma GLP-1 levels and improves glucose tolerance in diabetic mice following oral glucose challenge.

Compound Libraries for DPPI 1c hydrochloride

DPPI 1c hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for DPPI 1c hydrochloride

M. Wt 312.8
Formula C14H20N4O2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 866396-70-5
PubChem ID 11381415
Smiles O=C(CNC2(CO)CCCC2)N1[C@@H](C#N)CC[C@H]1C#N.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DPPI 1c hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 31.28 100
water 15.64 50

Preparing Stock Solutions for DPPI 1c hydrochloride

The following data is based on the product molecular weight 312.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.2 mL 15.98 mL 31.97 mL
5 mM 0.64 mL 3.2 mL 6.39 mL
10 mM 0.32 mL 1.6 mL 3.2 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets for DPPI 1c hydrochloride

Certificate of Analysis / Product Datasheet
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References for DPPI 1c hydrochloride

References are publications that support the biological activity of the product.

Wright et al (2006) cis-2-5-dicyanopyrrolidine inhibitors of dipeptidyl peptidase IV: synthesis and in vitro, in vivo, and X-ray crystallographic characterization. J.Med.Chem. 49 3068 PMID: 16722626

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Citations for DPPI 1c hydrochloride

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