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Biological Activity for Talabostat mesylate
Talabostat mesylate is a potent DPP IV inhibitor (IC50 values are <4, 4, 11, 310 and 560 nM at DPP4, DPP8, DPP9, DPP7 and FAP, respectively). Activates the inflammasome sensor protein NLRP1b and selectively triggers pyroptosis in monocytes and macrophages. Induces immune-mediated tumor regression in multiple mouse models of cancer. Orally bioavailable.
Technical Data for Talabostat mesylate
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Talabostat mesylate
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Talabostat mesylate
The following data is based on the product molecular weight 310.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.22 mL||16.12 mL||32.24 mL|
|5 mM||0.64 mL||3.22 mL||6.45 mL|
|10 mM||0.32 mL||1.61 mL||3.22 mL|
|50 mM||0.06 mL||0.32 mL||0.64 mL|
Product Datasheets for Talabostat mesylate
References for Talabostat mesylate
References are publications that support the biological activity of the product.
Okondo et al (2017) DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis. Nat.Chem.Biol. 13 46 PMID: 27820798
Okondo et al (2018) Inhibition of Dpp8/9 activates the Nlrp1b inflammasome. Cell Chem.Biol. 25 262 PMID: 29396289
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Keywords: Talabostat mesylate, Talabostat mesylate supplier, Potent, DPP, IV, inhibitors, inhibits, inflammasome, pyroptosis, Nlrp1b, BXCL701, DPP4, Val-boroPro, BXCL, 701, Dipeptidyl, Peptidase, (DPP-IV), Inflammasomes, 3719, Tocris Bioscience
Citations for Talabostat mesylate
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