Chemokine CC Receptors

Chemokine CC receptors (CCRs) predominantly recognize CC chemokines. CC chemokines are distinguished by having four conserved cysteines, with the first two cysteines being adjacent to each other. There are 10 chemokine CC receptors.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
2565 ZK 756326
Selective, non-peptide CCR8 agonist

Antagonists

Cat No Product Name / Activity
3129 BMS CCR2 22
High affinity, potent CCR2 antagonist
3496 BX 471
Potent, selective CCR1 antagonist
2769 BX 513 hydrochloride
Selective CCR1 antagonist
3581 C 021 dihydrochloride
Potent CCR4 antagonist
2423 DAPTA
Chemokine receptor 5 (CCR5) antagonist
4306 INCB 3284 dimesylate
Selective CCR2 antagonist
2595 J 113863
Potent CCR1 chemokine receptor antagonist
5176 JNJ 27141491
Potent and selective human CCR2 antagonist
3756 Maraviroc
Selective CCR5 antagonist
2089 RS 102895 hydrochloride
CCR2b chemokine receptor antagonist
2517 RS 504393
Highly selective CCR2 chemokine receptor antagonist
4213 SB 297006
Potent and selective CCR3 antagonist
3650 SB 328437
Potent and selective CCR3 antagonist
3664 Teijin compound 1
Potent CCR2b antagonist
2757 UCB 35625
Potent CCR1 and CCR3 antagonist

Chemokine CC receptors (CCRs) predominantly recognize CC chemokines. CC chemokines are distinguished by having four conserved cysteines, although a small subgroup has six cysteines, with the first two cysteines being adjacent to one another. There are 10 chemokine CC receptors, with each one having a distinct chemokine and leukocyte specificity.

CC chemokines have a key role in the recruitment of monocytes and macrophages, cells types that are important in a number of chronic inflammatory conditions, such as atherosclerosis, rheumatoid arthritis, adipose inflammation, multiple sclerosis, asthma and Crohn's disease. CCR antagonists have been investigated clinically for these and other disorders. In addition, CCR5 acts as a coreceptor for HIV entry into CD4+ cells and antagonists of CCR5, such as maraviroc, have been developed to treat HIV infection.

External sources of pharmacological information for Chemokine CC Receptors :

Literature for Chemokine CC Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Asthma

Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.

Chemokine CC Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
CCR1 Human CCR1 NM_001295 P32246
Mouse Ccr1 NM_009912 P51675
Rat Ccr1 NM_020542 NP_065417
CCR2 Human CCR2 NM_000647 P41597
Mouse Ccr2 NM_009915 P51683
Rat Ccr2 NM_021866 O55193
CCR3 Human CCR3 NM_178328 P51677
Mouse Ccr3 NM_009914 P51678
Rat Ccr3 NM_053958 O54814
CCR4 Human CCR4 NM_005508 P51679
Mouse Ccr4 NM_009916 P51680
Rat Ccr4 NM_133532 NP_598216
CCR5 Human CCR5 NM_000579 P51681
Mouse Ccr5 NM_009917 P51682
Rat Ccr5 NM_053960 O08556
CCR6 Human CCR6 NM_031409 P51684
Mouse Ccr6 NM_009835 NP_001013163
Rat Ccr6 NM_001013145 Q5BK58
CCR7 Human CCR7 NM_001838 P32248
Mouse Ccr7 NM_007719 P47774
Rat Ccr7 NM_199489 Q6U2D6
CCR8 Human CCR8 NM_005201 P51685
Mouse Ccr8 NM_007720 P56484
CCR9 Human CCR9 NM_006641 P51686
Mouse Ccr9 NM_001166625 Q9WUT7
Rat Ccr9 NM_172329 NP_758832
CCR10 Human CCR10 NM_016602 P46092
Mouse Ccr10 NM_007721 Q9JL21
Rat Ccr10 NM_001108836 NP_001102306