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Potent and selective CCR4 antagonist (pIC50 = 7.8). Exhibits no activity at CXCR1 and CXCR2, CCR1, CCR2b, CCR5, CCR7, and CCR8 at 10 μM, and no significant activity when screened against a panel of 120 receptors and enzymes. Inhibits CCL22 Ca2+ response and Th2 cell CCL17/22 driven chemotaxis in vitro. Inhibits lung inflammation following antigen challenge in ovalbumin- sensitized rats.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 334.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.99 mL||14.96 mL||29.92 mL|
|5 mM||0.6 mL||2.99 mL||5.98 mL|
|10 mM||0.3 mL||1.5 mL||2.99 mL|
|50 mM||0.06 mL||0.3 mL||0.6 mL|
References are publications that support the biological activity of the product.
Toogood et al (2017) Small molecule immuno-oncology therapeutic agents. Bioorg.Med.Chem.Lett. S0960 31218 PMID: 29326017
Kindon et al (2017) Discovery of AZD-2098 and AZD-1678, two potent and bioavailable CCR4 receptor antagonists. ACS Med.Chem.Lett. 8 981 PMID: 28947948
Mullard et al (2014) Cancer charity sees success re-prioritizing industry's shelved compounds. Nat.Rev.Drug Discov. 13 319 PMID: 24781536
If you know of a relevant reference for AZD 2098, please let us know.
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Keywords: AZD 2098, AZD 2098 supplier, AZD2098, potent, selective, CCR4, chemokines, receptors, antagonists, antagonism, chemotaxis, Chemokine, CC, Receptors, 6541, Tocris Bioscience
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Literature in this Area
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Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.