AZD 2098

Pricing Availability   Qty
Cat.No. 6541 - AZD 2098 | C11H9Cl2N3O3S | CAS No. 566203-88-1
Description: Potent and selective CCR4 antagonist
Chemical Name: 2,3-Dichloro-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective CCR4 antagonist (pIC50 = 7.8). Exhibits no activity at CXCR1 and CXCR2, CCR1, CCR2b, CCR5, CCR7, and CCR8 at 10 μM, and no significant activity when screened against a panel of 120 receptors and enzymes. Inhibits CCL22 Ca2+ response and Th2 cell CCL17/22 driven chemotaxis in vitro. Inhibits lung inflammation following antigen challenge in ovalbumin- sensitized rats.

Technical Data

M. Wt 334.18
Formula C11H9Cl2N3O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 566203-88-1
PubChem ID 10308720
InChI Key FLSMVCMSUNISFK-UHFFFAOYSA-N
Smiles COC1=NC=CN=C1NS(=O)(C2=C(Cl)C(Cl)=CC=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.42 100
ethanol 3.34 10

Preparing Stock Solutions

The following data is based on the product molecular weight 334.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.99 mL 14.96 mL 29.92 mL
5 mM 0.6 mL 2.99 mL 5.98 mL
10 mM 0.3 mL 1.5 mL 2.99 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Toogood et al (2017) Small molecule immuno-oncology therapeutic agents. Bioorg.Med.Chem.Lett. S0960 31218 PMID: 29326017

Kindon et al (2017) Discovery of AZD-2098 and AZD-1678, two potent and bioavailable CCR4 receptor antagonists. ACS Med.Chem.Lett. 8 981 PMID: 28947948

Mullard et al (2014) Cancer charity sees success re-prioritizing industry's shelved compounds. Nat.Rev.Drug Discov. 13 319 PMID: 24781536


If you know of a relevant reference for AZD 2098, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Chemokine CC Receptor Antagonists

Keywords: AZD 2098, AZD 2098 supplier, AZD2098, potent, selective, CCR4, chemokines, receptors, antagonists, antagonism, chemotaxis, Chemokine, CC, Receptors, 6541, Tocris Bioscience

Citations for AZD 2098

Citations are publications that use Tocris products.

Currently there are no citations for AZD 2098. Do you know of a great paper that uses AZD 2098 from Tocris? Please let us know.

Reviews for AZD 2098

There are currently no reviews for this product. Be the first to review AZD 2098 and earn rewards!

Have you used AZD 2098?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Asthma

Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.