AZD 2098

Pricing Availability   Qty
Description: Potent and selective CCR4 antagonist
Chemical Name: 2,3-Dichloro-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for AZD 2098

AZD 2098 is a potent and selective CCR4 antagonist (pIC50 = 7.8). Exhibits no activity at CXCR1 and CXCR2, CCR1, CCR2b, CCR5, CCR7, and CCR8 at 10 μM, and no significant activity when screened against a panel of 120 receptors and enzymes. Inhibits CCL22 Ca2+ response and Th2 cell CCL17/22 driven chemotaxis in vitro. Inhibits lung inflammation following antigen challenge in ovalbumin- sensitized rats.

Compound Libraries for AZD 2098

AZD 2098 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for AZD 2098

M. Wt 334.18
Formula C11H9Cl2N3O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 566203-88-1
PubChem ID 10308720
Smiles COC1=NC=CN=C1NS(=O)(C2=C(Cl)C(Cl)=CC=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AZD 2098

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.42 100
ethanol 3.34 10

Preparing Stock Solutions for AZD 2098

The following data is based on the product molecular weight 334.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.99 mL 14.96 mL 29.92 mL
5 mM 0.6 mL 2.99 mL 5.98 mL
10 mM 0.3 mL 1.5 mL 2.99 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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References for AZD 2098

References are publications that support the biological activity of the product.

Toogood et al (2017) Small molecule immuno-oncology therapeutic agents. Bioorg.Med.Chem.Lett. S0960 31218 PMID: 29326017

Kindon et al (2017) Discovery of AZD-2098 and AZD-1678, two potent and bioavailable CCR4 receptor antagonists. ACS Med.Chem.Lett. 8 981 PMID: 28947948

Mullard et al (2014) Cancer charity sees success re-prioritizing industry's shelved compounds. Nat.Rev.Drug Discov. 13 319 PMID: 24781536

If you know of a relevant reference for AZD 2098, please let us know.

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Citations for AZD 2098

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Literature in this Area

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